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      Spin‐selective electron transmission through self‐assembled monolayers of double‐stranded peptide nucleic acid

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          PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules.

          DNA analogues are currently being intensely investigated owing to their potential as gene-targeted drugs. Furthermore, their properties and interaction with DNA and RNA could provide a better understanding of the structural features of natural DNA that determine its unique chemical, biological and genetic properties. We recently designed a DNA analogue, PNA, in which the backbone is structurally homomorphous with the deoxyribose backbone and consists of N-(2-aminoethyl)glycine units to which the nucleobases are attached. We showed that PNA oligomers containing solely thymine and cytosine can hybridize to complementary oligonucleotides, presumably by forming Watson-Crick-Hoogsteen (PNA)2-DNA triplexes, which are much more stable than the corresponding DNA-DNA duplexes, and bind to double-stranded DNA by strand displacement. We report here that PNA containing all four natural nucleobases hybridizes to complementary oligonucleotides obeying the Watson-Crick base-pairing rules, and thus is a true DNA mimic in terms of base-pair recognition.
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            Spin selectivity in electron transmission through self-assembled monolayers of double-stranded DNA.

            In electron-transfer processes, spin effects normally are seen either in magnetic materials or in systems containing heavy atoms that facilitate spin-orbit coupling. We report spin-selective transmission of electrons through self-assembled monolayers of double-stranded DNA on gold. By directly measuring the spin of the transmitted electrons with a Mott polarimeter, we found spin polarizations exceeding 60% at room temperature. The spin-polarized photoelectrons were observed even when the photoelectrons were generated with unpolarized light. The observed spin selectivity at room temperature was extremely high as compared with other known spin filters. The spin filtration efficiency depended on the length of the DNA in the monolayer and its organization.
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              Chiral molecules and the electron spin

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                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                Chirality
                Chirality
                Wiley
                0899-0042
                1520-636X
                February 2021
                January 05 2021
                February 2021
                : 33
                : 2
                : 93-102
                Affiliations
                [1 ]Center for Soft Nanoscience (SoN) Westfälische Wilhelms‐Universität Münster Münster Germany
                [2 ]Department of Chemistry Carnegie Mellon University Pittsburgh PA USA
                [3 ]Department of Chemical and Biological Physics Weizmann Institute of Science Rehovot Israel
                Article
                10.1002/chir.23290
                33400337
                ee5ea2f2-bcc5-4437-a1c6-bb94a2eb229b
                © 2021

                http://creativecommons.org/licenses/by-nc/4.0/

                http://creativecommons.org/licenses/by-nc/4.0/

                http://doi.wiley.com/10.1002/tdm_license_1.1

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