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      Evaluation of Statewide Restrictions on Flavored e-Cigarette Sales in the US From 2014 to 2020

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          Abstract

          This cross-sectional study assesses the association of statewide restrictions on flavored e-cigarette sales in Massachusetts, New York, Rhode Island, and Washington with total e-cigarette unit sales from 2014 to 2020.

          Key Points

          Question

          Were statewide restrictions on flavored e-cigarette sales in Massachusetts, New York, Rhode Island, and Washington associated with a reduction in total e-cigarette unit sales from 2014 to 2020?

          Findings

          In this cross-sectional study, a difference-in-differences analysis of e-cigarette retail data showed that statewide restrictions on non–tobacco-flavored e-cigarette sales were associated with reductions of 25.01% to 31.26% in total e-cigarette unit sales compared with total sales in states without restrictions. The reductions were attributable mostly to decreases in non–tobacco-flavored e-cigarette sales.

          Meaning

          In this study, statewide restrictions on sales of non–tobacco-flavored e-cigarettes were associated with reductions in e-cigarette sales.

          Abstract

          Importance

          e-Cigarettes are the most commonly used tobacco product among US youths. Flavors are among the most cited reasons for use of e-cigarettes among youths, and therefore, some states have imposed restrictions on flavored e-cigarette sales. To our knowledge, no study has compared e-cigarette sales between states with statewide flavored e-cigarette restrictions and states without such restrictions while controlling for co-occurring events.

          Objective

          To assess whether implementation of statewide restrictions on flavored e-cigarette sales in Massachusetts, New York, Rhode Island, and Washington was associated with a reduction in total e-cigarette unit sales from 2014 to 2020.

          Design, Setting, and Participants

          This cross-sectional study with difference-in-differences analysis used e-cigarette retail sales data from Massachusetts, Rhode Island, and Washington, which implemented restrictions on flavored e-cigarette sales in October 2019; New York, which implemented these restrictions in May 2020; and 35 states without these restrictions (control states). Sales were summed into 4-week periods from August 24, 2014, to December 27, 2020, for a total of 2988 state-period observations.

          Main Outcomes and Measures

          A difference-in-differences analysis was conducted to compare e-cigarette unit sales in the 4 states with flavor restrictions (before and after implementation) with those in the 35 control states. The model controlled for other population-based policies and emergent events (eg, the COVID-19 pandemic). Data on 4-week e-cigarette unit sales were sorted into 4 flavor categories (tobacco, menthol, mint, and other). Unit sales were standardized to reflect the most common package sizes for each product type.

          Results

          Statewide restrictions on non–tobacco-flavored e-cigarette sales were associated with the following reductions in mean 4-week total e-cigarette sales in intervention states compared with control states from October 2019 to December 2020: 30.65% (95% CI, 24.08%-36.66%) in New York, 31.26% (95% CI, 11.94%-46.34%) in Rhode Island, and 25.01% (95% CI, 18.43%-31.05%) in Washington. In Massachusetts, the comprehensive sales prohibition of all e-cigarette products was associated with a 94.38% (95% CI, 93.37%-95.23%) reduction in 4-week sales compared with control states. Except in Massachusetts, where all sales of flavored e-cigarettes decreased, reductions were found only for non–tobacco-flavored e-cigarette sales in the other states with restrictions. Among control states, mean sales decreased by 28.4% from August 2019 to February 2020 but then increased by 49.9% from February through December 2020.

          Conclusions and Relevance

          In this cross-sectional study, statewide restrictions on the sale of flavored e-cigarettes in Massachusetts, New York, Rhode Island, and Washington were associated with a reduction in total e-cigarette sales. These findings suggest that not all e-cigarette users who purchased non–tobacco-flavored e-cigarettes switched to purchasing tobacco-flavored e-cigarettes after policy implementation.

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          Most cited references29

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          Designing Difference in Difference Studies: Best Practices for Public Health Policy Research

          The difference in difference (DID) design is a quasi-experimental research design that researchers often use to study causal relationships in public health settings where randomized controlled trials (RCTs) are infeasible or unethical. However, causal inference poses many challenges in DID designs. In this article, we review key features of DID designs with an emphasis on public health policy research. Contemporary researchers should take an active approach to the design of DID studies, seeking to construct comparison groups, sensitivity analyses, and robustness checks that help validate the method's assumptions. We explain the key assumptions of the design and discuss analytic tactics, supplementary analysis, and approaches to statistical inference that are often important in applied research. The DID design is not a perfect substitute for randomized experiments, but it often represents a feasible way to learn about casual relationships. We conclude by noting that combining elements from multiple quasi-experimental techniques may be important in the next wave of innovations to the DID approach.
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            E-cigarette Use Among Middle and High School Students — United States, 2020

            The use of any tobacco product by youths is unsafe, including electronic cigarettes (e-cigarettes) (1). Most e-cigarettes contain nicotine, which is highly addictive, can harm the developing adolescent brain, and can increase risk for future addiction to other drugs (1). E-cigarette use has increased considerably among U.S. youths since 2011 ( 1 , 2 ). Multiple factors have contributed to this increase, including youth-appealing flavors and product innovations ( 1 – 3 ). Amid the widespread use of e-cigarettes and popularity of certain products among youths, on February 6, 2020, the Food and Drug Administration (FDA) implemented a policy prioritizing enforcement against the manufacture, distribution, and sale of certain unauthorized flavored prefilled pod or cartridge-based e-cigarettes (excluding tobacco or menthol).* CDC and FDA analyzed nationally representative data from the 2020 National Youth Tobacco Survey (NYTS),† a cross-sectional, school-based, self-administered survey of U.S. middle school (grades 6–8) and high school (grades 9–12) students conducted during January 16–March 16, 2020. § The NYTS study protocol was approved by the CDC institutional review board. Current (past 30-day) e-cigarette use was assessed, overall and by device ¶ and flavor** type. Weighted prevalence estimates and population totals †† were calculated. Analyses were conducted using SAS-callable SUDAAN (version 11.0.3; RTI International). In 2020, 19.6% of high school students (3.02 million) and 4.7% of middle school students (550,000) reported current e-cigarette use. Among current e-cigarette users, 38.9% of high school students and 20.0% of middle school students reported using e-cigarettes on 20 or more of the past 30 days; 22.5% of high school users and 9.4% of middle school users reported daily use. Among all current e-cigarette users, 82.9% used flavored e-cigarettes, including 84.7% of high school users (2.53 million) and 73.9% of middle school users (400,000). Among high school current e-cigarette users, the most commonly used device type was prefilled pods or cartridges (48.5%; 1.45 million), followed by disposables (26.5%; 790,000), and tanks (14.8%; 440,000). Among middle school current e-cigarette users, the most commonly used device type was prefilled pods or cartridges (41.3%; 220,000), followed by tanks (21.5%; 110,000), and disposables (15.2%; 80,000). Among high school students who currently used any type of flavored e-cigarettes, the most commonly used flavor types were fruit (73.1%; 1.83 million); mint (55.8%; 1.39 million); menthol (37.0%; 920,000); and candy, desserts, or other sweets (36.4%; 910,000). Among middle school students who currently used any type of flavored e-cigarettes, the most commonly used flavor types were fruit (75.6%; 290,000); candy, desserts, or other sweets (47.2%; 180,000); mint (46.5%; 180,000); and menthol (23.5%; 90,000). Among current users of flavored prefilled pods or cartridges, the most commonly used flavor types were fruit (66.0%; 920,000); mint (57.5%; 800,000); menthol (44.5%; 620,000); and candy, desserts, or other sweets (35.6%; 490,000) (Figure). Among current users of flavored disposable e-cigarettes, the most commonly used flavor types were fruit (82.7%; 650,000), mint (51.9%; 410,000); candy, desserts, or other sweets (41.7%; 330,000); and menthol (23.3%; 180,000). FIGURE Percentage of flavor types used by current (past 30-day) flavored e-cigarette users among U.S. middle and high school students,* by device type†, § — National Youth Tobacco Survey, United States, 2020 * Flavor type use among current (past 30-day) users of flavored e-cigarettes was determined by answers to the question “What flavors were the e-cigarettes that you have used in the past 30 days? (Select one or more).” Response options were “menthol,” “mint,” “clove or spice,” “fruit,” “chocolate,” “alcoholic drinks (such as wine, cognac, margarita, or other cocktails),” “candy, desserts, or other sweets,” and “some other flavor not listed here” (write-in responses were not assessed). Data for “clove or spice” are not shown because of statistically unreliable estimates due to unweighted denominator 30% across all device types. † Device type use among current e-cigarette users was determined by answers to the question “Which of the following best describes the type of e-cigarette you have used in the past 30 days? If you have used more than one type, please think about the one you use most often.” Response options were “a disposable e-cigarette,” “an e-cigarette that uses pre-filled pods or cartridges (e.g., JUUL),” “an e-cigarette with a tank that you refill with liquids,” “a mod system (an e-cigarette that can be customized by the user with their own combination of batteries or other parts),” and “I don’t know the type.” § The following data were statistically unreliable and not shown due to unweighted denominator 30%: use of chocolate flavor types among current flavored e-cigarette users of disposable e-cigarettes, mod systems, or those who reported “I don’t know the type” for device type; alcoholic drink flavor types among current flavored e-cigarette users of mod systems or those who reported “I don’t know the type” for device type; and “some other flavor” among current flavored e-cigarette users who reported “I don’t know the type” for device type. The figure is a bar chart showing the percentage of flavor types used by current (past 30-day) flavored e-cigarette users among U.S. middle and high school students, by device type in the United States during 2020 according to the National Youth Tobacco Survey. In 2020, approximately one in five high school students and one in 20 middle school students currently used e-cigarettes. By comparison, in 2019, 27.5% of high school students (4.11 million) and 10.5% of middle school students (1.24 million) reported current e-cigarette use ( 2 ). Although these data reflect a decline in current e-cigarette use since 2019, 3.6 million U.S. youths still currently used e-cigarettes in 2020, and among current users, more than eight in 10 reported using flavored e-cigarettes. Consistent with 2019, prefilled pods or cartridges were the most commonly used device type in 2020; however, during 2019–2020, disposable e-cigarette use increased approximately 1,000% (from 2.4% to 26.5%) among high school current e-cigarette users and approximately 400% (from 3.0% to 15.2%) among middle school current e-cigarette users. Although use of fruit flavored e-cigarettes was common among users in 2020, findings also suggest prominent menthol e-cigarette use, including among nearly one half of flavored prefilled pod or cartridge users and one quarter of flavored disposable product users. Comprehensive implementation of evidence-based strategies at the national, state, and local levels, in coordination with FDA regulation, can prevent and reduce youth tobacco product use ( 1 , 4 , 5 ). Strategies to address factors driving youth e-cigarette use are particularly critical. In addition to FDA’s enforcement policy that prohibits the sale of prefilled pod or cartridge-based e-cigarettes in any flavor other than tobacco or menthol, several states and communities have restricted all flavored e-cigarette sales, including menthol. §§
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              Tobacco Product Use Among Middle and High School Students — United States, 2020

              Tobacco use is the leading cause of preventable disease and death in the United States; nearly all tobacco product use begins during youth and young adulthood ( 1 , 2 ). CDC and the Food and Drug Administration (FDA) analyzed data from the 2019 and 2020 National Youth Tobacco Surveys (NYTS) to determine changes in the current (past 30-day) use of seven tobacco products among U.S. middle (grades 6–8) and high (grades 9–12) school students. In 2020, current use of any tobacco product was reported by 16.2% (4.47 million) of all students, including 23.6% (3.65 million) of high school and 6.7% (800,000) of middle school students. Electronic cigarettes (e-cigarettes) were the most commonly used tobacco product among high school (19.6%; 3.02 million) and middle school (4.7%; 550,000) students. From 2019 to 2020, decreases in current use of any tobacco product, any combustible tobacco product, multiple tobacco products, e-cigarettes, cigars, and smokeless tobacco occurred among high school and middle school students; these declines resulted in an estimated 1.73 million fewer current youth tobacco product users in 2020 than in 2019 (6.20 million) ( 3 ). From 2019 to 2020, no significant change occurred in the use of cigarettes, hookahs, pipe tobacco, or heated tobacco products. The comprehensive and sustained implementation of evidence-based tobacco control strategies at the national, state, and local levels, combined with tobacco product regulation by FDA, is warranted to help sustain this progress and to prevent and reduce all forms of tobacco product use among U.S. youths ( 1 , 2 ). NYTS is a cross-sectional, voluntary, school-based, self-administered electronic survey of U.S. middle and high school students. A stratified three-stage cluster sampling procedure generated a nationally representative sample of U.S. students attending public and private schools in grades 6–12. Participants complete the survey in classrooms using a tablet computer.* In 2020, data collection occurred during January 16–March 16, 2020. † In total, 14,531 students (participation rate = 87.4%) from 180 schools (participation rate = 49.9%) participated, yielding an overall response rate of 43.6% in 2020. Detailed information about NYTS is available elsewhere. § Prevalence, with 95% confidence intervals, of current use of seven tobacco products (e-cigarettes, cigarettes, cigars, smokeless tobacco, ¶ hookahs, pipe tobacco,** and heated tobacco products †† ) was reported; current use was defined as use on one or more days during the past 30 days. Three composite measures of current use (any tobacco product, §§ any combustible tobacco product, ¶¶ and multiple tobacco products***) also were reported. National weighted prevalence estimates and population totals ††† in 2020 were reported among all students and separately by school level. Estimates were reported overall and by selected demographic characteristics. Differences between the prevalence of current use in 2020 and that in 2019 (19,018 participants in 2019; student participation rate = 85.8%; school participation rate = 77.2%; overall response rate = 66.3%) were estimated using t-tests; p-values 30% or an unweighted denominator of 30%. ** In 2020, any tobacco product use was defined as use of any tobacco product (e-cigarettes, cigarettes, cigars, smokeless tobacco, hookahs, pipe tobacco, bidis [small brown cigarettes wrapped in a leaf], or heated tobacco products) on ≥1 day during the past 30 days. †† Any combustible tobacco product use was defined as use of cigarettes, cigars, hookahs, pipe tobacco, or bidis on ≥1 day during the past 30 days. §§ In 2020, multiple tobacco product use was defined as use of two or more tobacco products (e-cigarettes, cigarettes, cigars, smokeless tobacco, hookahs, pipe tobacco, bidis, or heated tobacco products) on ≥1 day during the past 30 days. Among middle school students, 6.7% (800,000) reported current use of any tobacco product, 3.4% (400,000; 50.7% of any tobacco product users) reported current use of any combustible tobacco product, and 2.8% (340,000; 41.8% of any tobacco product users) reported current use of multiple tobacco products. By type of product, current use among middle school students was highest for e-cigarettes (4.7%), followed by cigarettes (1.6%), cigars (1.5%), hookahs (1.3%), heated tobacco products (1.3%), smokeless tobacco (1.2%), and pipe tobacco (0.4%). Among middle school students, any tobacco product use was reported by 6.8% of females and 6.6% of males; by 9.4% of Hispanic, 6.7% of non-Hispanic Black, and 5.7% of non-Hispanic White students; and by 16.5% of those identifying as lesbian, gay, or bisexual, 5.5% of those identifying as heterosexual, and 6.4% of those reporting “not sure” about their sexual identity. From 2019 to 2020, among high school (Figure 1) and middle school students (Figure 2), significant declines (p 30% or unweighted denominator <50. § In 2020, any tobacco product use was defined as use of any tobacco product (e-cigarettes, cigarettes, cigars, smokeless tobacco, hookahs, pipe tobacco, bidis [small brown cigarettes wrapped in a leaf], or heated tobacco products) on ≥1 day during the past 30 days. In 2019, consistent with previously published estimates, any tobacco product use was defined as use of any tobacco product (e-cigarettes, cigarettes, cigars, smokeless tobacco, hookahs, pipe tobacco, or bidis) on ≥1 day during the past 30 days. ¶ Any combustible tobacco product use was defined as use of cigarettes, cigars, hookahs, pipe tobacco, or bidis on ≥1 day during the past 30 days. ** In 2020, multiple tobacco product use was defined as use of two or more tobacco products (e-cigarettes, cigarettes, cigars, smokeless tobacco, hookahs, pipe tobacco, bidis, or heated tobacco products) on ≥1 day during the past 30 days. In 2019, consistent with previously published estimates, multiple tobacco product use was defined as use of two or more tobacco products (e-cigarettes, cigarettes, cigars, smokeless tobacco, hookahs, pipe tobacco, or bidis) on ≥1 day during the past 30 days. †† During 2019–2020, significant declines in the use of any tobacco product (p<0.001), any combustible tobacco product (p = 0.013), multiple tobacco products (p = 0.025), e-cigarettes (p<0.001), cigars (p = 0.012), and smokeless tobacco (p = 0.038) were observed. No significant change in use of cigarettes, hookahs, or heated tobacco products occurred. Because of the suppression of the pipe tobacco estimate in 2019, no comparison was made during 2019–2020. The figure is a bar chart showing the percentage of current use of selected tobacco products, any tobacco product, any combustible tobacco product, and multiple tobacco products among middle school students in the United States during 2019 and 2020 according to the National Youth Tobacco Survey. Discussion Use of any tobacco product by youths declined by an estimated 1.73 million from 6.20 million in 2019 ( 3 ) to 4.47 million in 2020. Despite this decline, in 2020 nearly one in four U.S. high school students and approximately one in 15 middle school students still reported current use of any tobacco product. Continued efforts are warranted to sustain this progress and to prevent and reduce all forms of tobacco product use among U.S. youths ( 1 , 2 ). Among both middle and high school students, current use of e-cigarettes declined from 2019 to 2020, reversing previous trends and returning current e-cigarette use to levels similar to those observed in 2018 ( 4 ). Declines in current cigar smoking and smokeless tobacco product use also occurred, as did youths’ use of any combustible tobacco products and multiple tobacco products. Together, these changes contributed to an overall reduction in any tobacco product use by youths during 2019–2020. These declines were likely attributable to multiple factors at the national, state, and local level. For example, in December 2019, the federal minimum age of sale of all tobacco product types increased from 18 to 21 years ( 5 ). Under the authority of the 2009 Family Smoking Prevention and Tobacco Control Act, FDA issued guidance in January 2020 to prioritize enforcement against certain flavored e-cigarette products that appeal to youths, including mint and fruit flavors ( 6 ). Several states and communities also recently restricted the sale of flavored tobacco products, including e-cigarettes. §§§ In addition, public health efforts to address the multistate outbreak of e-cigarette, or vaping, product use–associated lung injury (EVALI) might have contributed to these declines in youth e-cigarette use ( 7 ). Furthermore, targeted actions to address the youth e-cigarette epidemic occurred, including FDA’s public education campaign to reduce youth e-cigarette, smokeless tobacco, and cigarette use. ¶¶¶ Despite declines in youths’ use of combustible tobacco products since 2011 ( 4 ), no change in current cigarette smoking occurred during 2019–2020. Among all students who currently used any tobacco product, approximately 42% (1.87 million) reported smoking combustible tobacco products in 2020. However, a decline in current cigar smoking did occur during 2019–2020. Continued actions are warranted to help ensure sustained progress in preventing and reducing youths’ use of all forms of tobacco products, including those that are combustible, noncombustible, and electronic. The findings in this report are subject to at least three limitations. First, the data collection period was truncated because of the coronavirus disease 2019 pandemic, resulting in a lower school participation rate (49.9%) compared with recent NYTS cycles (average across 2011–2019 NYTS cycles = 78.2%). However, the 2020 NYTS student participation rate (87.4%) was high, and the weighted sample yielded nationally representative estimates.**** Second, these data were self-reported and might be subject to recall and response biases. Finally, these findings might not be generalizable to youths who are homeschooled, have dropped out of school, are in detention centers, or are enrolled in alternative schools. In 2020, approximately one in six U.S. middle and high school students, or approximately 4.47 million youths overall, reported current use of any tobacco product. The comprehensive and sustained implementation of evidence-based tobacco control strategies at the national, state, and local levels, combined with tobacco product regulation by FDA, is warranted for continuing progress toward reducing and preventing all forms of tobacco product use among U.S. youths. Such strategies include increasing prices of tobacco products, protecting persons from exposure to secondhand smoke and e-cigarette aerosol, sustaining hard-hitting media campaigns that warn about the dangers of tobacco product use, restricting youth access to tobacco products, prohibiting the sale of all flavored tobacco products, and development of regulations to reduce youth appeal and addictiveness of tobacco products ( 1 – 3 , 8 – 10 ). In addition, as the tobacco product landscape continues to diversify, surveillance for all forms of tobacco product use, including novel products, by youths is important to inform public health policy and practice at the local, state, and national levels. Summary What is already known? Tobacco use is the leading cause of preventable disease and death in the United States; nearly all tobacco use begins during youth and young adulthood. What is added by this report? In 2020, 23.6% (3.65 million) of high school and 6.7% (800,000) of middle school students reported current (past 30-day) use of any tobacco product. From 2019 to 2020, decreases among high school and middle school students occurred in current use of any tobacco product, combustible tobacco products, multiple tobacco products, e-cigarettes, cigars, and smokeless tobacco. What are the implications for public health? The comprehensive and sustained implementation of evidence-based tobacco control strategies, combined with tobacco product regulation by the Food and Drug Administration, is warranted to help sustain this progress and prevent and reduce all forms of tobacco product use among U.S. youths.
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                Author and article information

                Journal
                JAMA Netw Open
                JAMA Netw Open
                JAMA Network Open
                American Medical Association
                2574-3805
                10 February 2022
                February 2022
                10 February 2022
                : 5
                : 2
                : e2147813
                Affiliations
                [1 ]CDC Foundation, Atlanta, Georgia
                [2 ]Truth Initiative, Washington, DC
                [3 ]Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia
                Author notes
                Article Information
                Accepted for Publication: December 2, 2021.
                Published: February 10, 2022. doi:10.1001/jamanetworkopen.2021.47813
                Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Ali FRM et al. JAMA Network Open.
                Corresponding Author: Fatma Romeh M. Ali, PhD, CDC Foundation, 600 Peachtree St NE, Ste 1000, Atlanta, GA 30308 ( fali@ 123456cdcfoundation.org ).
                Author Contributions: Dr Ali had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
                Concept and design: Ali, Vallone, Diaz, Tynan, Trivers, King.
                Acquisition, analysis, or interpretation of data: Ali, Seaman, Cordova, Trivers, King.
                Drafting of the manuscript: Ali, Seaman, Cordova, Trivers, King.
                Critical revision of the manuscript for important intellectual content: Ali, Vallone, Diaz, Tynan, Trivers, King.
                Statistical analysis: Ali, Diaz.
                Obtained funding: King.
                Administrative, technical, or material support: Ali, Vallone, Seaman, Cordova, Trivers, King.
                Supervision: Ali, Vallone, Tynan, King.
                Conflict of Interest Disclosures: Dr Ali reported receiving grants from Bloomberg Philanthropies to the CDC Foundation during the conduct of the study. Dr Vallone reported receiving financial support from a CDC Foundation subcontract through Bloomberg Philanthropies during the conduct of the study. Dr Seaman reported receiving grants from Bloomberg Philanthropies during the conduct of the study. Dr Cordova reported receiving grants from Bloomberg Philanthropies during the conduct of the study. Dr Diaz reported receiving grants from the CDC Foundation during the conduct of the study. No other disclosures were reported.
                Funding/Support: This research was supported through a Bloomberg Philanthropies grant to the CDC Foundation.
                Role of the Funder/Sponsor: Bloomberg Philanthropies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
                Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention.
                Article
                zoi211312
                10.1001/jamanetworkopen.2021.47813
                8832173
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                ed96fa84-190a-474b-a013-2f1ae66fdd75
                Copyright 2022 Ali FRM et al. JAMA Network Open.

                This is an open access article distributed under the terms of the CC-BY License.

                History
                : 21 September 2021
                : 2 December 2021
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                Public Health

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