Sample size calculation in medical studies

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Abstract

Optimum sample size is an essential component of any research. The main purpose of the sample size calculation is to determine the number of samples needed to detect significant changes in clinical parameters, treatment effects or associations after data gathering. It is not uncommon for studies to be underpowered and thereby fail to detect the existing treatment effects due to inadequate sample size. In this paper, we explain briefly the basic principles of sample size calculations in medical studies.

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Author and article information

Journal

Journal ID (nlm-ta): Gastroenterol Hepatol Bed Bench

Journal ID (iso-abbrev): Gastroenterol Hepatol Bed Bench

Journal ID (publisher-id): GHFBB

Title: Gastroenterology and Hepatology From Bed to Bench

Publisher: Research Institute for Gastroenterology and Liver Diseases

ISSN (Print): 2008-2258

ISSN (Electronic): 2008-4234

Publication date (Print): Winter 2013

Volume: 6

Issue: 1

Pages: 14-17

Affiliations

[1 ]Department of Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

[2 ]Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

[3 ]Alborz University of Medical Sciences, Karaj, Iran

Author notes

Reprint or Correspondence: Mohsen Vahedi, PhD Student. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. E-mail: mohsenvahedi540@ 123456gmail.com

Article

Publisher ID: GHFBB-6-014

DOI: 10.22037/ghfbb.v6i1.332

PMC ID: 4017493

PubMed ID: 24834239

SO-VID: a55b81cb-77d3-4261-9e96-3922a680ef19

License:

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

History

Date received : 15 October 2012

Date accepted : 18 December 2012

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