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Studies on the mechanism of action of the aptamer BAX499, an Inhibitor of tissue factor pathway inhibitor
September 2012
September 2012
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Abstract
Promoting thrombin generation by inhibiting tissue factor pathway inhibitor (TFPI)
is a potentially viable therapeutic approach to the prevention and/or treatment of
bleeding in hemophilia. In this report, we studied the interaction between an aptamer
(BAX499; formerly ARC19499) and TFPI that resulted in inhibition of TFPI-mediated
regulation of the tissue factor pathway.