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      A three-timepoint network analysis of Covid-19’s impact on schizotypal traits, paranoia and mental health through loneliness

      research-article
      1 , * , , 2 , 3 , 4 , 5 , 6
      UCL Open Environment
      UCL Press
      network analysis, schizotypy, paranoia, anxiety, depression, stress, loneliness, sleep, Covid-19, longitudinal, mental health

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          Abstract

          The 2019 coronavirus (Covid-19) pandemic has impacted people’s mental wellbeing. Studies to date have examined the prevalence of mental health symptoms (anxiety and depression), yet fewer longitudinal studies have compared across background factors and other psychological variables to identify vulnerable subgroups in the general population. This study tests to what extent higher levels of schizotypal traits and paranoia are associated with mental health variables 6- and 12-months since April 2020. Over 2300 adult volunteers (18–89 years, female = 74.9%) with access to the study link online were recruited from the UK, the USA, Greece and Italy. Self-reported levels of schizotypy, paranoia, anxiety, depression, aggression, loneliness and stress from three timepoints (17 April to 13 July 2020, N 1 = 1599; 17 October to 31 January 2021, N 2 = 774; and 17 April to 31 July 2021, N 3 = 586) were mapped using network analysis and compared across time and background variables (sex, age, income, country). Schizotypal traits and paranoia were positively associated with poorer mental health through loneliness, with no effect of age, sex, income levels, countries and timepoints. Loneliness was the most influential variable across all networks, despite overall reductions in levels of loneliness, schizotypy, paranoia and aggression during the easing of lockdown (time 3). Individuals with higher levels of schizotypal traits/paranoia reported poorer mental health outcomes than individuals in the low-trait groups. Schizotypal traits and paranoia are associated with poor mental health outcomes through self-perceived feelings of loneliness, suggesting that increasing social/community cohesion may improve individuals’ mental wellbeing in the long run.

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          Most cited references53

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          A brief measure for assessing generalized anxiety disorder: the GAD-7.

          Generalized anxiety disorder (GAD) is one of the most common mental disorders; however, there is no brief clinical measure for assessing GAD. The objective of this study was to develop a brief self-report scale to identify probable cases of GAD and evaluate its reliability and validity. A criterion-standard study was performed in 15 primary care clinics in the United States from November 2004 through June 2005. Of a total of 2740 adult patients completing a study questionnaire, 965 patients had a telephone interview with a mental health professional within 1 week. For criterion and construct validity, GAD self-report scale diagnoses were compared with independent diagnoses made by mental health professionals; functional status measures; disability days; and health care use. A 7-item anxiety scale (GAD-7) had good reliability, as well as criterion, construct, factorial, and procedural validity. A cut point was identified that optimized sensitivity (89%) and specificity (82%). Increasing scores on the scale were strongly associated with multiple domains of functional impairment (all 6 Medical Outcomes Study Short-Form General Health Survey scales and disability days). Although GAD and depression symptoms frequently co-occurred, factor analysis confirmed them as distinct dimensions. Moreover, GAD and depression symptoms had differing but independent effects on functional impairment and disability. There was good agreement between self-report and interviewer-administered versions of the scale. The GAD-7 is a valid and efficient tool for screening for GAD and assessing its severity in clinical practice and research.
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            The PHQ-9: validity of a brief depression severity measure.

            While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity. The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as "0" (not at all) to "3" (nearly every day). The PHQ-9 was completed by 6,000 patients in 8 primary care clinics and 7 obstetrics-gynecology clinics. Construct validity was assessed using the 20-item Short-Form General Health Survey, self-reported sick days and clinic visits, and symptom-related difficulty. Criterion validity was assessed against an independent structured mental health professional (MHP) interview in a sample of 580 patients. As PHQ-9 depression severity increased, there was a substantial decrease in functional status on all 6 SF-20 subscales. Also, symptom-related difficulty, sick days, and health care utilization increased. Using the MHP reinterview as the criterion standard, a PHQ-9 score > or =10 had a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 represented mild, moderate, moderately severe, and severe depression, respectively. Results were similar in the primary care and obstetrics-gynecology samples. In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity. These characteristics plus its brevity make the PHQ-9 a useful clinical and research tool.
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              Regression Shrinkage and Selection Via the Lasso

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                Author and article information

                Journal
                UCL Open Environ
                UCLOE
                UCL Open Environment
                UCL Open Environ
                UCL Press (UK )
                2632-0886
                01 November 2022
                2022
                : 4
                : e044
                Affiliations
                [1 ]Department of Psychology and Human Development, University College London, London, UK
                [2 ]Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
                [3 ]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
                [4 ]Department of Psychology and Cognitive Science, University of Trento, Rovereto, Italy
                [5 ]Psychology Program, School of Social Sciences, Nanyang Technological University, Singapore, Singapore
                [6 ]Departments of Criminology, Psychiatry, and Psychology, University of Pennsylvania, Philadelphia, PA, USA
                Author notes
                *Corresponding author: E-mail: keri.wong@ 123456ucl.ac.uk
                Author information
                https://orcid.org/0000-0002-2962-8438
                Article
                10.14324/111.444/ucloe.000044
                10208351
                37228468
                72603996-debb-4f50-9928-a222569be629
                © 2022 The Authors.

                This is an open access article distributed under the terms of the Creative Commons Attribution Licence (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

                History
                : 02 September 2021
                : 16 August 2022
                Page count
                Figures: 12, Tables: 7, References: 54, Pages: 23
                Categories
                Research Article

                Covid-19,sleep,loneliness,stress,depression,anxiety,paranoia,schizotypy,network analysis,mental health,longitudinal

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