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      Accurate Deep Neural Network Model to Detect Cardiac Arrhythmia on More Than 10,000 Individual Subject ECG Records

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          Highlights

          • DNN model is proposed to detect arrhythmia.

          • More than 10,000 individual subject ECG records subject records are used.

          • Two different scenarios are employed: (i) reduced rhythms (seven rhythm types) and (ii) merged rhythms (four rhythm types).

          • Achieved 92.24% and 96.13% accuracies for the reduced and merged rhythm classes, respectively.

          • System can aid cardiologists in the accurate detection of arrhythmia accurately.

          Abstract

          Background and objective

          : Cardiac arrhythmia, which is an abnormal heart rhythm, is a common clinical problem in cardiology. Detection of arrhythmia on an extended duration electrocardiogram (ECG) is done based on initial algorithmic software screening, with final visual validation by cardiologists. It is a time consuming and subjective process. Therefore, fully automated computer-assisted detection systems with a high degree of accuracy has an essential role in this task. In this study, we proposed an effective deep neural network (DNN) model to detect different rhythm classes from a new ECG database.

          Methods

          : Our DNN model was designed for high performance on all ECG leads. The proposed model, which included both representation learning and sequence learning tasks, showed promising results on all 12-lead inputs. Convolutional layers and sub-sampling layers were used in the representation learning phase. The sequence learning part involved a long short-term memory (LSTM) unit after representation of learning layers.

          Results

          : We performed two different class scenarios, including reduced rhythms (seven rhythm types) and merged rhythms (four rhythm types) according to the records from the database. Our trained DNN model achieved 92.24% and 96.13% accuracies for the reduced and merged rhythm classes, respectively.

          Conclusion

          : Recently, deep learning algorithms have been found to be useful because of their high performance. The main challenge is the scarcity of appropriate training and testing resources because model performance is dependent on the quality and quantity of case samples. In this study, we used a new public arrhythmia database comprising more than 10,000 records. We constructed an efficient deep neural network (DNN) model for automated detection of arrhythmia using these records.

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          Most cited references65

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          Automated detection of COVID-19 cases using deep neural networks with X-ray images

          The novel coronavirus 2019 (COVID-2019), which first appeared in Wuhan city of China in December 2019, spread rapidly around the world and became a pandemic. It has caused a devastating effect on both daily lives, public health, and the global economy. It is critical to detect the positive cases as early as possible so as to prevent the further spread of this epidemic and to quickly treat affected patients. The need for auxiliary diagnostic tools has increased as there are no accurate automated toolkits available. Recent findings obtained using radiology imaging techniques suggest that such images contain salient information about the COVID-19 virus. Application of advanced artificial intelligence (AI) techniques coupled with radiological imaging can be helpful for the accurate detection of this disease, and can also be assistive to overcome the problem of a lack of specialized physicians in remote villages. In this study, a new model for automatic COVID-19 detection using raw chest X-ray images is presented. The proposed model is developed to provide accurate diagnostics for binary classification (COVID vs. No-Findings) and multi-class classification (COVID vs. No-Findings vs. Pneumonia). Our model produced a classification accuracy of 98.08% for binary classes and 87.02% for multi-class cases. The DarkNet model was used in our study as a classifier for the you only look once (YOLO) real time object detection system. We implemented 17 convolutional layers and introduced different filtering on each layer. Our model (available at (https://github.com/muhammedtalo/COVID-19)) can be employed to assist radiologists in validating their initial screening, and can also be employed via cloud to immediately screen patients.
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            Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network

            Computerized electrocardiogram (ECG) interpretation plays a critical role in the clinical ECG workflow1. Widely available digital ECG data and the algorithmic paradigm of deep learning2 present an opportunity to substantially improve the accuracy and scalability of automated ECG analysis. However, a comprehensive evaluation of an end-to-end deep learning approach for ECG analysis across a wide variety of diagnostic classes has not been previously reported. Here, we develop a deep neural network (DNN) to classify 12 rhythm classes using 91,232 single-lead ECGs from 53,549 patients who used a single-lead ambulatory ECG monitoring device. When validated against an independent test dataset annotated by a consensus committee of board-certified practicing cardiologists, the DNN achieved an average area under the receiver operating characteristic curve (ROC) of 0.97. The average F1 score, which is the harmonic mean of the positive predictive value and sensitivity, for the DNN (0.837) exceeded that of average cardiologists (0.780). With specificity fixed at the average specificity achieved by cardiologists, the sensitivity of the DNN exceeded the average cardiologist sensitivity for all rhythm classes. These findings demonstrate that an end-to-end deep learning approach can classify a broad range of distinct arrhythmias from single-lead ECGs with high diagnostic performance similar to that of cardiologists. If confirmed in clinical settings, this approach could reduce the rate of misdiagnosed computerized ECG interpretations and improve the efficiency of expert human ECG interpretation by accurately triaging or prioritizing the most urgent conditions.
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              A Review of Image Denoising Algorithms, with a New One

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                Author and article information

                Journal
                Comput Methods Programs Biomed
                Comput Methods Programs Biomed
                Computer Methods and Programs in Biomedicine
                Elsevier B.V.
                0169-2607
                1872-7565
                8 September 2020
                8 September 2020
                : 105740
                Affiliations
                [a ]Department of Computer Engineering, Munzur University, Tunceli,62000, Turkey
                [b ]Department of Software Engineering, Firat University, Elazig, Turkey
                [c ]Department of Medicine - Division of Cardiology, Columbia University Medical Center, New York, NY, 10032, USA
                [d ]National Heart Centre, Singapore, Singapore
                [e ]Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, Singapore
                [f ]Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan
                [g ]School of Management and Enterprise University of Southern Queensland, Springfield, Australia
                Author notes
                [* ]Corresponding author. Dr U Rajendra Acharya, Ngee Ann Polytechnic, 535 Clementi Road, Singapore 599489, Singapore
                Article
                S0169-2607(20)31573-X 105740
                10.1016/j.cmpb.2020.105740
                7477611
                32932129
                e37f88be-1a52-4db1-8538-6b1142d08923
                © 2020 Elsevier B.V. All rights reserved.

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                : 1 August 2020
                : 31 August 2020
                Categories
                Article

                Bioinformatics & Computational biology
                arrhythmia detection,deep neural networks,ecg signals,12-lead ecg

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