Identification of a novel transposon-associated phosphoethanolamine transferase gene, mcr-5, conferring colistin resistance in d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B.

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Abstract

Plasmid-mediated mobilized colistin resistance is currently known to be caused by phosphoethanolamine transferases termed MCR-1, MCR-2, MCR-3 and MCR-4. However, this study focuses on the dissection of a novel resistance mechanism in mcr-1-, mcr-2- and mcr-3-negative d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B (Salmonella Paratyphi B dTa+) isolates with colistin MIC values >2 mg/L.

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Journal

Journal ID (iso-abbrev): J. Antimicrob. Chemother.

Title: The Journal of antimicrobial chemotherapy

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2091

ISSN (Print): 0305-7453

Publication date (Electronic): Dec 01 2017

Volume: 72

Issue: 12

Affiliations

[1 ] German Federal Institute for Risk Assessment, BfR, Department for Biological Safety, Berlin, Germany.

[2 ] National Food Institute, Technical University of Denmark, WHO Collaborating Center for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kgs Lyngby, Denmark.

Article

Publisher Item ID: 4161410

DOI: 10.1093/jac/dkx327

PubMed ID: 28962028

SO-VID: d2cb3dd8-7555-46f0-8a0d-d0fcc4239726

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