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      Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri

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          Abstract

          Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids. The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s13659-022-00344-1.

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          Homoharringtonine/omacetaxine mepesuccinate: the long and winding road to food and drug administration approval.

          Andrés J. Cortés, H Kantarjian, Susan O’Brien (2013)
          Homoharringtonine/omacetaxine is a unique agent with a long history of research development. It has been recently approved by the Food and Drug Administration for the treatment of chronic myeloid leukemia after failure of 2 or more tyrosine kinase inhibitors. Research with this agent has spanned over 40 years, with many instructive lessons to cancer research, which are summarized in this review. Copyright © 2013 Elsevier Inc. All rights reserved.
          Article 0 comments Cited 30 times – based on 0 reviews     Review now
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            Structures of harringtonine, isoharringtonine, and homoharringtonine.

            R.G. Powell, D Weisleder, C.R. Smith … (1970)
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              Natural products from Cephalotaxus sp.: chemical diversity and synthetic aspects.

              Bastien Nay, Hajer Abdelkafi (2012)
              The Cephalotaxus genus belongs to the Cephalotaxaceae family of conifers. Over the past decades it has proved to be a fruitful source of interesting natural products, especially alkaloids (cephalotaxine esters) and terpenoids (abietanes, troponoids), which often display medicinal properties, especially in the anticancer area. Homoharringtonine is active against some orphan leukaemia and is nowadays approaching marketability. A phytochemical update will be provided and the total synthesis of alkaloids and terpenoids will be discussed in detail.
              Article 0 comments Cited 23 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Xiang-Hai Cai:
                ORCID: http://orcid.org/0000-0002-6723-6988
                xhcai@mail.kib.ac.cn
                Journal
                Journal ID (nlm-ta): Nat Prod Bioprospect
                Journal ID (iso-abbrev): Nat Prod Bioprospect
                Title: Natural Products and Bioprospecting
                Publisher: Springer Nature Singapore (Singapore )
                ISSN (Print): 2192-2195
                ISSN (Electronic): 2192-2209
                Publication date (Electronic): 1 July 2022
                Publication date PMC-release: 1 July 2022
                Publication date Collection: December 2022
                Volume: 12
                Issue: 1
                Electronic Location Identifier: 24
                Affiliations
                [1 ]GRID grid.458460.b, ISNI 0000 0004 1764 155X, State Key Laboratory of Phytochemistry and Plant Resources in West China, , Kunming Institute of Botany, Chinese Academy of Sciences, ; Kunming, 650201 People’s Republic of China
                [2 ]GRID grid.410726.6, ISNI 0000 0004 1797 8419, University of Chinese Academy of Sciences, ; Beijing, 100039 People’s Republic of China
                Author information
                http://orcid.org/0000-0002-6723-6988
                Article
                Publisher ID: 344
                DOI: 10.1007/s13659-022-00344-1
                PMC ID: 9249953
                PubMed ID: 35778536
                SO-VID: b51baabb-b347-49cb-ad5b-9e62ab753cf2
                Copyright © © The Author(s) 2022
                License:

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                Date received : 28 March 2022
                Date accepted : 12 April 2022
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
                Award ID: 31872677
                Award Recipient :
                Categories
                Subject: Original Article
                Custom metadata
                issue-copyright-statement © The Author(s) 2022

                Keywords: cephalotaxus oliveri,cephalotaxaceae,alkaloid,enantiomer
                Data availability:
                Keywords: cephalotaxus oliveri, cephalotaxaceae, alkaloid, enantiomer

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