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      Recent progress in melting heat phenomenon for bioconvection transport of nanofluid through a lubricated surface with swimming microorganisms

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          Abstract

          The cooling of numerous microelectronic devices has become a need in today's world. Nanofluids, a novel type of heat transport fluid containing nano-sized particles embedded in a host liquid, were developed a few years ago. Impact of ultra-fine nanoparticles with oil, water, or ethylene glycol produces these fluids. Nano-liquids have a variety of applications, including engine cooling, electronic devices, biomedicine, and the manufacture of thermal exchangers. The main objective of current research article is to scrutinizes theoretically, the effects of axisymmetric magnetohydrodynamic flow of bio-convective nanoliquid through a moving surface in the occurrence of swimming microorganisms. The idea of the envisaged model is improved by considering the consequence of thermal radiation, activation energy with generalized slip effects under convective boundaries. The present analysis is developed in the form of mathematical formulation and then solved numerically. The governing flow equations are transmuted into dimensionless nonlinear ODEs system by compatible similarity transformations and then integrated this so-formulated highly nonlinear problem numerically via bvp4c built-in scheme in MATLAB. The significance of influential parameters versus velocity field, temperature profile, concentration field and motile density of microorganism’s profile are examined with the aid of graphs and tabular data. The physical interpretation of outcomes highlight that the velocity receives increment for amplified mixed convection parameter. The thermal profile is found to be reducing with a greater Prandtl number. The concentration profile of nanoparticle boosts up for greater activation energy parameter. The microorganism’s profile is reduced via bioconvection Lewis number. This investigation contains the significance of bioconvection phenomenon, thermal radiation, slip effects and activation energy under convective boundary conditions. These impacts are used in axisymmetric, stagnation point flow of bioconvective magnetized nanofluid containing swimming gyrotactic motile microorganisms over a lubricated surface. The present analysis is not yet published.

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          Re-epithelialization and immune cell behaviour in an ex vivo human skin model

          A large body of literature is available on wound healing in humans. Nonetheless, a standardized ex vivo wound model without disruption of the dermal compartment has not been put forward with compelling justification. Here, we present a novel wound model based on application of negative pressure and its effects for epidermal regeneration and immune cell behaviour. Importantly, the basement membrane remained intact after blister roof removal and keratinocytes were absent in the wounded area. Upon six days of culture, the wound was covered with one to three-cell thick K14+Ki67+ keratinocyte layers, indicating that proliferation and migration were involved in wound closure. After eight to twelve days, a multi-layered epidermis was formed expressing epidermal differentiation markers (K10, filaggrin, DSG-1, CDSN). Investigations about immune cell-specific manners revealed more T cells in the blister roof epidermis compared to normal epidermis. We identified several cell populations in blister roof epidermis and suction blister fluid that are absent in normal epidermis which correlated with their decrease in the dermis, indicating a dermal efflux upon negative pressure. Together, our model recapitulates the main features of epithelial wound regeneration, and can be applied for testing wound healing therapies and investigating underlying mechanisms.
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            Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

            Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc patients and 92 age-/sex-matched healthy controls were recruited for the cross-sectional analysis. The longitudinal analysis comprised 30 patients with SSc associated interstitial lung disease (ILD) routinely treated with cyclophosphamide. Hsp90 was increased in SSc compared to healthy controls. Hsp90 correlated positively with C-reactive protein and negatively with pulmonary function tests: forced vital capacity and diffusing capacity for carbon monoxide (DLCO). In patients with diffuse cutaneous (dc) SSc, Hsp90 positively correlated with the modified Rodnan skin score. In SSc-ILD patients treated with cyclophosphamide, no differences in Hsp90 were found between baseline and after 1, 6, or 12 months of therapy. However, baseline Hsp90 predicts the 12-month change in DLCO. This study shows that Hsp90 plasma levels are increased in SSc patients compared to age-/sex-matched healthy controls. Elevated Hsp90 in SSc is associated with increased inflammatory activity, worse lung functions, and in dcSSc, with the extent of skin involvement. Baseline plasma Hsp90 predicts the 12-month change in DLCO in SSc-ILD patients treated with cyclophosphamide.
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              Convective Transport in Nanofluids

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                Author and article information

                Contributors
                hassanwaqas22@gcuf.edu.pk
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                19 May 2022
                19 May 2022
                2022
                : 12
                : 8447
                Affiliations
                [1 ]GRID grid.412144.6, ISNI 0000 0004 1790 7100, Department of Mathematics, College of Sciences, , King Khalid University, ; Abha, 61413 Saudi Arabia
                [2 ]GRID grid.411786.d, ISNI 0000 0004 0637 891X, Department of Mathematics, , Government College University Faisalabad, ; Faisalabad, 38000 Pakistan
                Article
                12230
                10.1038/s41598-022-12230-4
                9120440
                35589791
                a2934f91-b438-41f9-baf2-24c7cb4e4682
                © The Author(s) 2022

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 6 October 2021
                : 18 April 2022
                Categories
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                © The Author(s) 2022

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                biophysics,engineering,materials science,mathematics and computing,nanoscience and technology

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