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Abstract
Natural killer (NK)-cell receptors (NKRs) on CD8+ T cells can modulate antigen-specific
T-cell activity but their function and rules that govern their expression remain unclear.
Recent work has provided new insight into CD94-NKG2A expression on T cells. Whereas
upregulation on the cell surface is induced following T-cell receptor (TCR) engagement,
commitment to CD94-NKG2A expression is a clonal attribute. NKRs can therefore shape
cytotoxic T-lymphocyte (CTL) responses and should be considered in designing vaccine
therapies.