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      • Record: found
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      The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism

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      Author(s): a , b , a , c , a , d , a , b , e , a , c , a , f , g , a , d , a , e , a , c , a , f , a , f , a , e , a , f , a , d , a , d , a , e , a , f , a , b , e , a , c , a , d , a , d , a , b , a , f , a , e , a , d , a , d , a , c , a , d , a , c , a , c , a , f , a , c , a , b , a , d , a , c , a , h , a , e , a , f , a , c , a , b , e , a , d , f , a , f , *
      Publication date (Electronic):
      Journal: Acta Crystallographica Section F: Structural Biology and Crystallization Communications
      Publisher: International Union of Crystallography
      Conference name: Joint Center for Structural Genomics (JCSG) special issue
      Conference date:
      Keywords: structural genomics, DUFs, glycolipids, osmotic stress, host–pathogen interactions

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          Abstract

          PA1994, a Pfam PF06475 (DUF1089) family homolog from P. aeruginosa, reveals remote similarities to lipoprotein localization factors and a conserved putative glycolipid-binding site.

          Abstract

          The crystal structure of PA1994 from Pseudomonas aeruginosa, a member of the Pfam PF06475 family classified as a domain of unknown function (DUF1089), reveals a novel fold comprising a 15-stranded β-sheet wrapped around a single α-helix that assembles into a tight dimeric arrangement. The remote structural similarity to lipoprotein localization factors, in addition to the presence of an acidic pocket that is conserved in DUF1089 homologs, phospholipid-binding and sugar-binding proteins, indicate a role for PA1994 and the DUF1089 family in glycolipid metabolism. Genome-context analysis lends further support to the involvement of this family of proteins in glycolipid metabolism and indicates possible activation of DUF1089 homologs under conditions of bacterial cell-wall stress or host–pathogen interactions.

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          Author and article information

          Conference
          Journal ID (nlm-ta): Acta Crystallogr Sect F Struct Biol Cryst Commun
          Journal ID (publisher-id): Acta Cryst. F
          Title: Acta Crystallographica Section F: Structural Biology and Crystallization Communications
          Publisher: International Union of Crystallography
          ISSN (Electronic): 1744-3091
          Publication date Collection: 1 October 2010
          Publication date (Electronic): 27 October 2009
          Publication date PMC-release: 27 October 2009
          Volume: 66
          Issue: Pt 10 ( publisher-idID: f101000 )
          Pages: 1211-1217
          Affiliations
          [a ]Joint Center for Structural Genomics, http://www.jcsg.org, USA
          [b ]Program on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, CA, USA
          [c ]Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USA
          [d ]Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, CA, USA
          [e ]Center for Research in Biological Systems, University of California, San Diego, La Jolla, CA, USA
          [f ]Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
          [g ]Département de Biochimie, Université de Sherbrooke, Québec, Canada
          [h ]Photon Science, SLAC National Accelerator Laboratory, Menlo Park, CA, USA
          Author notes
          Correspondence e-mail: wilson@ 123456scripps.edu
          Article
          Publisher ID: wd5111 Coden ID: ACSFCL Publisher Item ID: S1744309109022684
          DOI: 10.1107/S1744309109022684
          PMC ID: 2954207
          PubMed ID: 20944213
          SO-VID: 8cb48d1b-82b4-4e9f-8fc4-fb8d8208fcfd
          Copyright © © Bakolitsa et al. 2010
          License:

          This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

          Conference name: Joint Center for Structural Genomics (JCSG) special issue
          Conference location:
          Conference date:
          History
          Date received : 16 April 2009
          Date accepted : 12 June 2009
          Categories
          Subject: New Folds

          ScienceOpen disciplines: Molecular biology
          Keywords: host–pathogen interactions,osmotic stress,dufs,glycolipids,structural genomics
          Data availability:
          ScienceOpen disciplines: Molecular biology
          Keywords: host–pathogen interactions, osmotic stress, dufs, glycolipids, structural genomics

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