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Neurotoxic reactive astrocytes are induced by activated microglia
Shane A. Liddelow ,
Kevin A. Guttenplan ,
Laura E. Clarke ,
Frederick C. Bennett ,
Christopher J. Bohlen ,
Lucas Schirmer ,
Mariko L. Bennett ,
Alexandra E. Münch ,
Won-Suk Chung ,
Todd C. Peterson ,
Daniel K. Wilton ,
Arnaud Frouin ,
Brooke A. Napier ,
Nikhil Panicker ,
Manoj Kumar ,
Marion S. Buckwalter ,
David H. Rowitch ,
Valina L. Dawson ,
Ted M. Dawson ,
Beth Stevens ,
Ben A. Barres
January 18 2017
January 18 2017
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Abstract
A reactive astrocyte subtype termed A1 is induced after injury or disease of the central nervous system and subsequently promotes the death of neurons and oligodendrocytes.