COVID-19 IN CHILDREN: SUMMARIZING WORLDWIDE EXPERIENCE TO DATE

Author(s): Yu.A. Ermolaeva , Yu.G. Samoilova , O.A. Oleinik , V.E. Yun , D.A. Kudlay , Siberian State Medical University (SSMU), Tomsk, Russia, Siberian State Medical University (SSMU), Tomsk, Russia, Siberian State Medical University (SSMU), Tomsk, Russia, Siberian State Medical University (SSMU), Tomsk, Russia, National Research Center Institute of Immunology of the Russian Federal Biomedical Agency, Moscow, Russia, I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Publication date Created: August 19 2022

Publication date (Electronic): August 19 2022

Journal: Pediatria. Journal named after G.N. Speransky

Publisher: Pediatria, Ltd.

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Abstract

The purpose of this bibliographical review is to provide an exceptional and up-to-date overview of COVID-19 infection in children describing its epidemiology, pathogenesis, clinical features and outcomes. The article provides a comprehensive analysis of publications by foreign and Russian authors on a new coronavirus infection (COVID-19) caused by SARS-CoV-2 in children. A complete clinical description of the course of COVID-19 in pediatric population is given: from asymptomatic virus carrying till the development of acute pneumonia, multi-inflammatory syndrome, multiple organ failure and death. Among the clinical manifestations there are described as follows: respiratory syndrome, gastrointestinal tract injury, manifestations in the central nervous system, lesions of the skin and mucous membranes and a complete characteristic of multi-inflammatory syndrome. The studied methods of development of COVID-19 are examined in pathogenesis. The issues of anti-tuberculosis vaccination, the impact of serum cholecalciferol level on the severity and outcomes of COVID-19 disease are highlighted. The latest publications on intrauterine infection of the fetus and the breast milk research for the presence of SARS-CoV-2 were analyzed.