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      Dry Powder Inhalers: A Focus on Advancements in Novel Drug Delivery Systems

      review-article
      Author(s): *
      Publication date (Electronic):
      Journal: Journal of Drug Delivery
      Publisher: Hindawi Publishing Corporation

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          Abstract

          Administration of drug molecules by inhalation route for treatment of respiratory diseases has the ability to deliver drugs, hormones, nucleic acids, steroids, proteins, and peptides, particularly to the site of action, improving the efficacy of the treatment and consequently lessening adverse effects of the treatment. Numerous inhalation delivery systems have been developed and studied to treat respiratory diseases such as asthma, COPD, and other pulmonary infections. The progress of disciplines such as biomaterials science, nanotechnology, particle engineering, molecular biology, and cell biology permits further improvement of the treatment capability. The present review analyzes modern therapeutic approaches of inhaled drugs with special emphasis on novel drug delivery system for treatment of various respiratory diseases.

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          Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications.

          Andreas Wicki, Dominik Witzigmann, Vimalkumar Balasubramanian … (2015)
          Cancer is a leading cause of death worldwide. Currently available therapies are inadequate and spur demand for improved technologies. Rapid growth in nanotechnology towards the development of nanomedicine products holds great promise to improve therapeutic strategies against cancer. Nanomedicine products represent an opportunity to achieve sophisticated targeting strategies and multi-functionality. They can improve the pharmacokinetic and pharmacodynamic profiles of conventional therapeutics and may thus optimize the efficacy of existing anti-cancer compounds. In this review, we discuss state-of-the-art nanoparticles and targeted systems that have been investigated in clinical studies. We emphasize the challenges faced in using nanomedicine products and translating them from a preclinical level to the clinical setting. Additionally, we cover aspects of nanocarrier engineering that may open up new opportunities for nanomedicine products in the clinic.
          Article 0 comments Cited 488 times – based on 0 reviews     Review now
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            Inhaled nanoparticles--a current review.

            Richard O. Williams, Philip J Peters, Wei Yang (2008)
            The field of nanotechnology may hold the promise of significant improvements in the health and well being of patients, as well as in manufacturing technologies. The knowledge of this impact of nanomaterials on public health is limited so far. This paper briefly reviews the unique size-controlled properties of nanomaterials, their disposition in the body after inhalation, and the factors influencing the fate of inhaled nanomaterials. The physiology of the lung makes it an ideal target organ for non-invasive local and systemic drug delivery, especially for protein and poorly water-soluble drugs that have low oral bioavailability via oral administration. The potential application of pulmonary drug delivery of nanoparticles to the lungs, specifically in context of published results reported on nanomaterials in environmental epidemiology and toxicology is reviewed in this paper.
            Article 0 comments Cited 121 times – based on 0 reviews     Review now
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              Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for pulmonary application: a review of the state of the art.

              Eric S. Weber, Jeanne Zimmer, J Pardeike (2014)
              Drug delivery by inhalation is a noninvasive means of administration that has following advantages for local treatment for airway diseases: reaching the epithelium directly, circumventing first pass metabolism and avoiding systemic toxicity. Moreover, from the physiological point of view, the lung provides advantages for systemic delivery of drugs including its large surface area, a thin alveolar epithelium and extensive vasculature which allow rapid and effective drug absorption. Therefore, pulmonary application is considered frequently for both, the local and the systemic delivery of drugs. Lipid nanoparticles - Solid Lipid Nanoparticles and Nanostructured Lipid Carriers - are nanosized carrier systems in which solid particles consisting of a lipid matrix are stabilized by surfactants in an aqueous phase. Advantages of lipid nanoparticles for the pulmonary application are the possibility of a deep lung deposition as they can be incorporated into respirables carriers due to their small size, prolonged release and low toxicity. This paper will give an overview of the existing literature about lipid nanoparticles for pulmonary application. Moreover, it will provide the reader with some background information for pulmonary drug delivery, i.e., anatomy and physiology of the respiratory system, formulation requirements, application forms, clearance from the lung, pharmacological benefits and nanotoxicity.
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Drug Deliv
                Journal ID (iso-abbrev): J Drug Deliv
                Journal ID (publisher-id): JDD
                Title: Journal of Drug Delivery
                Publisher: Hindawi Publishing Corporation
                ISSN (Print): 2090-3014
                ISSN (Electronic): 2090-3022
                Publication date (Print): 2016
                Publication date (Electronic): 27 October 2016
                Volume: 2016
                Electronic Location Identifier: 8290963
                Affiliations
                Dry Powder Inhaler Lab, Respiratory Formulations, Cipla R & D, LBS Road, Vikhroli (W), Mumbai, Maharashtra 400079, India
                Author notes

                Academic Editor: Ali Nokhodchi

                Author information
                http://orcid.org/0000-0001-6155-0135
                Article
                DOI: 10.1155/2016/8290963
                PMC ID: 5102732
                SO-VID: 7a80f6b9-b4ca-47a6-8947-283ec87ae995
                Copyright © Copyright © 2016 Piyush Mehta.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 11 August 2016
                Date revision received : 25 September 2016
                Date accepted : 9 October 2016
                Categories
                Subject: Review Article

                ScienceOpen disciplines: Pharmaceutical chemistry
                Data availability:
                ScienceOpen disciplines: Pharmaceutical chemistry

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