KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion.

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Abstract

The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of the DNA-dependent protein kinase complex. Here we demonstrate that KARP-1 gene expression is significantly up-regulated following exposure of cells to DNA damage. KARP-1 mRNA induction was completely dependent on the ataxia telangiectasia and p53 gene products, consistent with the presence of a p53 binding site within the second intron of the KARP-1 locus. These observations link ataxia telangiectasia, p53, and KARP-1 in a common pathway.

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Journal

Journal ID (iso-abbrev): Proc. Natl. Acad. Sci. U.S.A.

Title: Proceedings of the National Academy of Sciences of the United States of America

ISSN: 0027-8424

ISSN (Print): 0027-8424

Publication date (Electronic): Jun 23 1998

Volume: 95

Issue: 13

Affiliations

[1 ] Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.

Article

PMC ID: 22716

PubMed ID: 9636207

SO-VID: 75e8467e-18e8-409c-acc8-33e3917d5eec

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