There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Predictors and consequences of inadequate compliance with seizure medications were
assessed using a 10-item postal survey. Dose omissions were reported by 71% of the
661 respondents (2+/-2 doses of seizure medications), with 45% of patients reporting
a seizure after a missed dose, at some time during treatment. Dose omission was more
likely with longer use of seizure medications (more than 5 years, P<0.01). Having
seizures after missed doses was associated with number of seizure medication doses
(P=0.04) and number of seizure medication tablets/capsules (P=0.01). Odds ratios showed
that each increase in dose frequency (one, two, three, or four doses daily) increased
the likelihood of a seizure after a missed dose by 36%. Taking larger numbers of tablets/capsules
increased the odds of having a seizure after missed doses by 43%. These data provide
evidence that medication compliance remains an important issue in epilepsy treatment.