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      Risk of accidents and unintentional injuries in men and women with attention deficit hyperactivity disorder across the adult lifespan

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          Abstract

          Introduction

          Attention deficit hyperactivity disorder (ADHD) is associated with risk‐taking behavior, leading to accidents and unintentional injuries (summarized here as incidents). Main aim of this study is to determine if men and women with and without ADHD differ in the risk of mild (treated outpatient) and severe (treated inpatient) incidents across the adult lifespan (age groups: 18–29; 30–59, and ≥60 years). Secondary aim: investigate the role of comorbid mental disorders and drugs for the treatment of these comorbidities, and ADHD‐medication.

          Methods

          Using anonymized German claims data ( N = 4,575,027), adults with ADHD diagnosis during 2016–2019 ( N = 17,041) were compared with a 1:4 age and sex‐matched group without ADHD diagnosis. Regression analyses statistically tested group differences.

          Results

          Incidents occur in a U‐shaped form across the adult lifespan. Individuals with ADHD show the same pattern but at a substantially increased risk of both mild and severe incidents throughout the lifespan. Women without ADHD are at lower risk in young adulthood than men but at higher risk in older adulthood. Women with ADHD show the same pattern for severe incidents, but for mild incidents they have the highest risk throughout the lifespan. Co‐occurring anxiety disorder and the use of psycholeptics and ADHD‐medication decreased the incident risk.

          Conclusion

          We extend available knowledge which has hitherto focused on young adult males and traffic accidents. ADHD is associated with increased incidents across the adult lifespan, with distinct patterns regarding age, sex, and incident severity. An accurate diagnosis of ADHD in adulthood provides the first step towards prevention of accidents and unintentional injuries.

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          Most cited references26

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          Risk factors for falls among older adults: a review of the literature.

          Falls are one of the major causes of mortality and morbidity in older adults. Every year, an estimated 30-40% of patients over the age of 65 will fall at least once. Falls lead to moderate to severe injuries, fear of falling, loss of independence and death in a third of those patients. The direct costs alone from fall related injuries are a staggering 0.1% of all healthcare expenditures in the United States and up to 1.5% of healthcare costs in European countries. This figure does not include the indirect costs of loss of income both to the patient and caregiver, the intangible losses of mobility, confidence, and functional independence. Numerous studies have attempted to define the risk factors for falls in older adults. The present review provides a brief summary and update of the relevant literature, summarizing demographic and modifiable risk factors. The major risk factors identified are impaired balance and gait, polypharmacy, and history of previous falls. Other risk factors include advancing age, female gender, visual impairments, cognitive decline especially attention and executive dysfunction, and environmental factors. Recommendations for the clinician to manage falls in older patients are also summarized. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
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            Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study.

            Attention deficit hyperactivity disorder (ADHD) is a common mental disorder associated with factors that are likely to increase mortality, such as oppositional defiant disorder or conduct disorder, criminality, accidents, and substance misuse. However, whether ADHD itself is associated with increased mortality remains unknown. We aimed to assess ADHD-related mortality in a large cohort of Danish individuals.
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              Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan

              Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a substantial number of cases the disorder does not remit in puberty, but persists into adulthood. Both in childhood and adulthood, ADHD is characterised by substantial comorbidity including substance use, depression, anxiety, and accidents. However, course and symptoms of the disorder and the comorbidities may fluctuate and change over time, and even age of onset in childhood has recently been questioned. Available evidence to date is poor and largely inconsistent with regard to the predictors of persistence versus remittance. Likewise, the development of comorbid disorders cannot be foreseen early on, hampering preventive measures. These facts call for a lifespan perspective on ADHD from childhood to old age. In this selective review, we summarise current knowledge of the long-term course of ADHD, with an emphasis on clinical symptom and cognitive trajectories, treatment effects over the lifespan, and the development of comorbidities. Also, we summarise current knowledge and important unresolved issues on biological factors underlying different ADHD trajectories. We conclude that a severe lack of knowledge on lifespan aspects in ADHD still exists for nearly every aspect reviewed. We encourage large-scale research efforts to overcome those knowledge gaps through appropriately granular longitudinal studies.
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                Author and article information

                Contributors
                b.libutzki@umcg.nl
                Journal
                Acta Psychiatr Scand
                Acta Psychiatr Scand
                10.1111/(ISSN)1600-0447
                ACPS
                Acta Psychiatrica Scandinavica
                John Wiley and Sons Inc. (Hoboken )
                0001-690X
                1600-0447
                14 December 2022
                February 2023
                : 147
                : 2 ( doiID: 10.1111/acps.v147.2 )
                : 145-154
                Affiliations
                [ 1 ] Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE) University of Groningen, University Medical Center Groningen Groningen The Netherlands
                [ 2 ] Hochschule Niederrhein University of Applied Sciences Krefeld Germany
                [ 3 ] Department of Psychiatry, Psychotherapy and Psychosomatic Medicine University Hospital of Würzburg Würzburg Germany
                [ 4 ] Department of Psychiatry, Psychosomatic Medicine and Psychotherapy University Hospital Frankfurt Frankfurt am Main Germany
                Author notes
                [*] [* ] Correspondence

                Berit Libutzki, Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

                Email: b.libutzki@ 123456umcg.nl

                Author information
                https://orcid.org/0000-0002-0826-281X
                https://orcid.org/0000-0003-3057-6150
                https://orcid.org/0000-0002-8094-8859
                Article
                ACPS13524
                10.1111/acps.13524
                10107297
                36464800
                60469c93-e201-4f5b-aed7-289aa2b39cb4
                © 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 21 November 2022
                : 11 September 2022
                : 28 November 2022
                Page count
                Figures: 2, Tables: 2, Pages: 10, Words: 6503
                Funding
                Funded by: Hochschule Niederrhein , doi 10.13039/501100008033;
                Funded by: Horizon 2020 , doi 10.13039/100010661;
                Award ID: 667302
                Funded by: ECNP Network
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
                February 2023
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.2.7 mode:remove_FC converted:17.04.2023

                Clinical Psychology & Psychiatry
                accidental injuries,attention deficit disorder with hyperactivity (adhd),comorbidity,real‐world evidence,wounds and injuries

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