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      COVID-19 pandemic and mitigation strategies: implications for maternal and child health and nutrition

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          ABSTRACT

          Coronavirus disease 2019 (COVID-19) continues to ravage health and economic metrics globally, including progress in maternal and child nutrition. Although there has been focus on rising rates of childhood wasting in the short term, maternal and child undernutrition rates are also likely to increase as a consequence of COVID-19 and its impacts on poverty, coverage of essential interventions, and access to appropriate nutritious foods. Key sectors at particular risk of collapse or reduced efficiency in the wake of COVID-19 include food systems, incomes, and social protection, health care services for women and children, and services and access to clean water and sanitation. This review highlights key areas of concern for maternal and child nutrition during and in the aftermath of COVID-19 while providing strategic guidance for countries in their efforts to reduce maternal and child undernutrition. Rooted in learnings from the exemplars in Global Health's Stunting Reduction Exemplars project, we provide a set of recommendations that span investments in sectors that have sustained direct and indirect impact on nutrition. These include interventions to strengthen the food-supply chain and reducing food insecurity to assist those at immediate risk of food shortages. Other strategies could include targeted social safety net programs, payment deferrals, or tax breaks as well as suitable cash-support programs for the most vulnerable. Targeting the most marginalized households in rural populations and urban slums could be achieved through deploying community health workers and supporting women and community members. Community-led sanitation programs could be key to ensuring healthy household environments and reducing undernutrition. Additionally, several COVID-19 response measures such as contact tracing and self-isolation could also be exploited for nutrition protection. Global health and improvements in undernutrition will require governments, donors, and development partners to restrategize and reprioritize investments for the COVID-19 era, and will necessitate data-driven decision making, political will and commitment, and international unity.

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          Most cited references36

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          Estimates of the severity of coronavirus disease 2019: a model-based analysis

          Summary Background In the face of rapidly changing data, a range of case fatality ratio estimates for coronavirus disease 2019 (COVID-19) have been produced that differ substantially in magnitude. We aimed to provide robust estimates, accounting for censoring and ascertainment biases. Methods We collected individual-case data for patients who died from COVID-19 in Hubei, mainland China (reported by national and provincial health commissions to Feb 8, 2020), and for cases outside of mainland China (from government or ministry of health websites and media reports for 37 countries, as well as Hong Kong and Macau, until Feb 25, 2020). These individual-case data were used to estimate the time between onset of symptoms and outcome (death or discharge from hospital). We next obtained age-stratified estimates of the case fatality ratio by relating the aggregate distribution of cases to the observed cumulative deaths in China, assuming a constant attack rate by age and adjusting for demography and age-based and location-based under-ascertainment. We also estimated the case fatality ratio from individual line-list data on 1334 cases identified outside of mainland China. Using data on the prevalence of PCR-confirmed cases in international residents repatriated from China, we obtained age-stratified estimates of the infection fatality ratio. Furthermore, data on age-stratified severity in a subset of 3665 cases from China were used to estimate the proportion of infected individuals who are likely to require hospitalisation. Findings Using data on 24 deaths that occurred in mainland China and 165 recoveries outside of China, we estimated the mean duration from onset of symptoms to death to be 17·8 days (95% credible interval [CrI] 16·9–19·2) and to hospital discharge to be 24·7 days (22·9–28·1). In all laboratory confirmed and clinically diagnosed cases from mainland China (n=70 117), we estimated a crude case fatality ratio (adjusted for censoring) of 3·67% (95% CrI 3·56–3·80). However, after further adjusting for demography and under-ascertainment, we obtained a best estimate of the case fatality ratio in China of 1·38% (1·23–1·53), with substantially higher ratios in older age groups (0·32% [0·27–0·38] in those aged <60 years vs 6·4% [5·7–7·2] in those aged ≥60 years), up to 13·4% (11·2–15·9) in those aged 80 years or older. Estimates of case fatality ratio from international cases stratified by age were consistent with those from China (parametric estimate 1·4% [0·4–3·5] in those aged <60 years [n=360] and 4·5% [1·8–11·1] in those aged ≥60 years [n=151]). Our estimated overall infection fatality ratio for China was 0·66% (0·39–1·33), with an increasing profile with age. Similarly, estimates of the proportion of infected individuals likely to be hospitalised increased with age up to a maximum of 18·4% (11·0–7·6) in those aged 80 years or older. Interpretation These early estimates give an indication of the fatality ratio across the spectrum of COVID-19 disease and show a strong age gradient in risk of death. Funding UK Medical Research Council.
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            Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study

            Summary Background While the COVID-19 pandemic will increase mortality due to the virus, it is also likely to increase mortality indirectly. In this study, we estimate the additional maternal and under-5 child deaths resulting from the potential disruption of health systems and decreased access to food. Methods We modelled three scenarios in which the coverage of essential maternal and child health interventions is reduced by 9·8–51·9% and the prevalence of wasting is increased by 10–50%. Although our scenarios are hypothetical, we sought to reflect real-world possibilities, given emerging reports of the supply-side and demand-side effects of the pandemic. We used the Lives Saved Tool to estimate the additional maternal and under-5 child deaths under each scenario, in 118 low-income and middle-income countries. We estimated additional deaths for a single month and extrapolated for 3 months, 6 months, and 12 months. Findings Our least severe scenario (coverage reductions of 9·8–18·5% and wasting increase of 10%) over 6 months would result in 253 500 additional child deaths and 12 200 additional maternal deaths. Our most severe scenario (coverage reductions of 39·3–51·9% and wasting increase of 50%) over 6 months would result in 1 157 000 additional child deaths and 56 700 additional maternal deaths. These additional deaths would represent an increase of 9·8–44·7% in under-5 child deaths per month, and an 8·3–38·6% increase in maternal deaths per month, across the 118 countries. Across our three scenarios, the reduced coverage of four childbirth interventions (parenteral administration of uterotonics, antibiotics, and anticonvulsants, and clean birth environments) would account for approximately 60% of additional maternal deaths. The increase in wasting prevalence would account for 18–23% of additional child deaths and reduced coverage of antibiotics for pneumonia and neonatal sepsis and of oral rehydration solution for diarrhoea would together account for around 41% of additional child deaths. Interpretation Our estimates are based on tentative assumptions and represent a wide range of outcomes. Nonetheless, they show that, if routine health care is disrupted and access to food is decreased (as a result of unavoidable shocks, health system collapse, or intentional choices made in responding to the pandemic), the increase in child and maternal deaths will be devastating. We hope these numbers add context as policy makers establish guidelines and allocate resources in the days and months to come. Funding Bill & Melinda Gates Foundation, Global Affairs Canada.
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              Prevention and control of non-communicable diseases in the COVID-19 response

              Moving towards universal health coverage, promoting health and wellbeing, and protecting against health emergencies are the WHO global priorities 1 that are shared by the proposed WHO European Programme of Work 2020–25. 2 The coronavirus disease 2019 (COVID-19) pandemic has underlined the importance of interconnecting these strategic priorities. Of the six WHO regions, the European region is the most affected by non-communicable disease (NCD)-related morbidity and mortality 3 and the growth of the NCDs is concerning. Cardiovascular diseases, cancers, chronic respiratory diseases, and diabetes are among the leading causes of death and disability in the region, 3 and an increasing proportion of children and adults are living with overweight or obesity, 4 one of the major risk factors for NCDs. Prevention and control of NCDs are important during this pandemic because NCDs are major risk factors for patients with COVID-19. 5 Additionally, some of the restrictive measures such as lockdowns, social distancing, and travel restrictions to reduce the spread of infection in many countries impact specifically on people living with NCDs by limiting their activity, ability to secure healthy foods, and access to preventive or health promotion services. 6 The COVID-19 pandemic has had widespread health impacts, revealing the particular vulnerability of those with underlying conditions. In Italy, a recent report revealed that the majority (96·2%) of patients who have died in-hospital from COVID-19 had comorbidities, primarily NCDs; the most prevalent NCDs among these patients were hypertension (69·2%), type 2 diabetes (31·8%), ischaemic heart disease (28·2%), chronic obstructive pulmonary disease (16·9%), and cancer (16·3%). 7 An association between COVID-19 severity and NCDs has also been reported in Spain, 8 China, 9 and the USA. 10 However, many COVID-19 deaths also occur in older people who often have existing comorbidities. 11 Body-mass index (BMI) might also be associated with the severity of COVID-19; in China, patients with severe COVID-19 and non-survivors typically had a high BMI (>25 kg/m2). 12 The impact of COVID-19 response measures on NCDs is multifaceted. Physical distancing or quarantine can lead to poor management of NCD behavioural risk factors, including unhealthy diet, physical inactivity, tobacco use, and harmful use of alcohol. 13 Evidence from this and previous pandemics suggests that without proper management, chronic conditions can worsen due to stressful situations resulting from restrictions, insecure economic situations, and changes in normal health behaviours. As with other health service and preventive programmes, the postponement of routine medical appointments and tests can delay NCD management, while physical distancing, restricted access to primary health care units, pharmacies, and community services, alongside a reduction of transport links, all disrupt continuity of care for NCD patients. This disruption of routine health services and medical supplies risks increasing morbidity, disability, and avoidable mortality over time in NCD patients. Additionally, patients with severe obesity who require intensive care have increased patient management needs. 6 The prevention and control of NCDs have a crucial role in the COVID-19 response and an adaptive response is required to account for the needs of people with NCDs. Prevention of NCDs is important since the true scale of at-risk groups is probably underestimated, given that many cases of hypertension and diabetes are undiagnosed.14, 15 Communities and health systems need to be adaptive to both support and manage the increased risks of people with known NCDs and exercise sensitivity about the vulnerability of the large population with undiagnosed NCDs and those at increased risk of NCDs. The COVID-19 response and continued and strengthened focus on NCD prevention and management are key and interlinked aspects of public health at the present time. If the COVID-19 response is not adapted to encompass prevention and management of NCD risks, we will fail many people at a time when their vulnerability is heightened. What steps should be taken to adapt the COVID-19 response? The WHO Regional Office for Europe has started to develop a list of actions that could be adapted by countries to address the needs of those at risk of NCDs or who are already living with NCDs, together with practical considerations for teams developing COVID-19 response plans at local or national levels (table ). Table Responses and risks related to NCD prevention and control during the COVID-19 pandemic NCD-specific responses Associated risks Community transmission with containment measures such as physical distancing and public service and institution closures or restrictions Lengthened time spent indoors Use technology to provide knowledge and support for management of NCDs, online information on exercise and mental health self-management classes, healthy recipes for home preparation, and online delivery of healthy foods, among other responses Reduced physical activity and increased strain on mental health might result in greater consumption of unhealthy foods and harmful use of tobacco and alcohol Family members at home Provide special arrangements for families with NCD patients to self-isolate Risk of increased contact with younger family members at home Inadequate access to medicines Use telemedicine more, allow local or community doctors and pharmacists to renew or extend drug prescriptions, deliver essential NCD drugs to home Shortage of essential medicines such as insulin and other NCD-specific medications Transport and other services restricted Prioritise and ensure continued community level services in a safe way to cater for NCD patients' needs Restricted transport facilities and family support for continued NCD care Infection control Early detection and laboratory testing Prioritise NCD patients for COVID-19 testing; triaging should take account of whether patients have NCDs and are immunocompromised Those NCD patients for whom visits to health facilities are essential could be at greater risk of getting exposed to COVID-19 Contact tracing Focus especially on those with increased risk factors for NCDs and NCD patients (ie, patients living with obesity) and alert and follow up closely any possible contacts for NCD patients NCD patients might be unaware of the additional risks posed on them Extensive testing Prioritise NCD patients for testing when possible and promote the need for testing NCD patients might be less motivated or able to actively seek testing (in a safe, physically distanced manner) Health-care settings (infection control) Provide NCD patients and health-care staff working in NCD services with special training and personal protective equipment, as well as health-care professionals at increased risk of NCDs NCD patients with comorbidities are at increased risk of infection; health-care staff working in NCD clinics are therefore also at increased risk of infection NCD=non-communicable disease. COVID-19=coronavirus disease 2019. Patients living with obesity and NCDs are at increased risk of the health impacts of emergencies such as COVID-19. 16 NCD health-care staff and associated workers and volunteers should be centrally involved in the planning of COVID-19 response strategies to ensure that the needs of patients and caregivers are addressed. Specific advice should be made available nationally and locally for patients living with NCDs, their families, and their caregivers. Prevention and control of obesity and NCDs are crucial in preparedness for this and future public health threats. A streamlined response to COVID-19 in the context of NCDs is important to optimise public health outcomes and reduce the impacts of this pandemic on individuals, vulnerable groups, key workers, and society.
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                Author and article information

                Contributors
                Journal
                Am J Clin Nutr
                Am. J. Clin. Nutr
                ajcn
                The American Journal of Clinical Nutrition
                Oxford University Press
                0002-9165
                1938-3207
                19 June 2020
                : nqaa171
                Affiliations
                Centre for Global Child Health, Hospital for Sick Children , Toronto, Canada
                Gates Ventures , Seattle, WA, USA
                Centre for Global Child Health, Hospital for Sick Children , Toronto, Canada
                Centre for Global Child Health, Hospital for Sick Children , Toronto, Canada
                Center of Excellence in Women and Child Health, Aga Khan University , Karachi, Pakistan
                Author notes
                Address correspondence to ZAB (e-mail: zulfiqar.bhutta@ 123456sickkids.ca )
                Article
                nqaa171
                10.1093/ajcn/nqaa171
                7337702
                32559276
                44b5a59c-c327-44ef-ae99-a942b778b0af
                Copyright © The Author(s) on behalf of the American Society for Nutrition 2020.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 27 May 2020
                : 08 June 2020
                Page count
                Pages: 6
                Categories
                Special Article
                AcademicSubjects/MED00060
                AcademicSubjects/MED00160
                Custom metadata
                PAP

                Nutrition & Dietetics
                covid-19,stunting,nutrition,interventions,children,women
                Nutrition & Dietetics
                covid-19, stunting, nutrition, interventions, children, women

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