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      Toward Sustainable Environmental Quality: Priority Research Questions for Asia

      review-article
      1 , 2 , , 1 , 3 , 4 , 5 , 6 , 1 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 12 , 24 , 25 , 26 , 27 , 28 , 18 , 29 , 30 , 31 , 32 , 3 , 10
      Environmental Toxicology and Chemistry
      John Wiley and Sons Inc.
      Environmental chemistry, Environmental toxicology, Hazard/risk assessment, Biomonitoring, Climate change

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          Abstract

          Environmental and human health challenges are pronounced in Asia, an exceptionally diverse and complex region where influences of global megatrends are extensive and numerous stresses to environmental quality exist. Identifying priorities necessary to engage grand challenges can be facilitated through horizon scanning exercises, and to this end we identified and examined 23 priority research questions needed to advance toward more sustainable environmental quality in Asia, as part of the Global Horizon Scanning Project. Advances in environmental toxicology, environmental chemistry, biological monitoring, and risk‐assessment methodologies are necessary to address the adverse impacts of environmental stressors on ecosystem services and biodiversity, with Asia being home to numerous biodiversity hotspots. Intersections of the food–energy–water nexus are profound in Asia; innovative and aggressive technologies are necessary to provide clean water, ensure food safety, and stimulate energy efficiency, while improving ecological integrity and addressing legacy and emerging threats to public health and the environment, particularly with increased aquaculture production. Asia is the largest chemical‐producing continent globally. Accordingly, sustainable and green chemistry and engineering present decided opportunities to stimulate innovation and realize a number of the United Nations Sustainable Development Goals. Engaging the priority research questions identified herein will require transdisciplinary coordination through existing and nontraditional partnerships within and among countries and sectors. Answering these questions will not be easy but is necessary to achieve more sustainable environmental quality in Asia. Environ Toxicol Chem 2020;39:1485–1505. © 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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          Most cited references102

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          Environmental DNA metabarcoding: Transforming how we survey animal and plant communities

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            Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation.

            There are concerns that selection pressure from antibiotics in the environment may accelerate the evolution and dissemination of antibiotic-resistant pathogens. Nevertheless, there is currently no regulatory system that takes such risks into account. In part, this is due to limited knowledge of environmental concentrations that might exert selection for resistant bacteria. To experimentally determine minimal selective concentrations in complex microbial ecosystems for all antibiotics would involve considerable effort. In this work, our aim was to estimate upper boundaries for selective concentrations for all common antibiotics, based on the assumption that selective concentrations a priori need to be lower than those completely inhibiting growth. Data on Minimal Inhibitory Concentrations (MICs) were obtained for 111 antibiotics from the public EUCAST database. The 1% lowest observed MICs were identified, and to compensate for limited species coverage, predicted lowest MICs adjusted for the number of tested species were extrapolated through modeling. Predicted No Effect Concentrations (PNECs) for resistance selection were then assessed using an assessment factor of 10 to account for differences between MICs and minimal selective concentrations. The resulting PNECs ranged from 8 ng/L to 64 μg/L. Furthermore, the link between taxonomic similarity between species and lowest MIC was weak. This work provides estimated upper boundaries for selective concentrations (lowest MICs) and PNECs for resistance selection for all common antibiotics. In most cases, PNECs for selection of resistance were below available PNECs for ecotoxicological effects. The generated PNECs can guide implementation of compound-specific emission limits that take into account risks for resistance promotion.
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              Non-target screening with high-resolution mass spectrometry: critical review using a collaborative trial on water analysis.

              In this article, a dataset from a collaborative non-target screening trial organised by the NORMAN Association is used to review the state-of-the-art and discuss future perspectives of non-target screening using high-resolution mass spectrometry in water analysis. A total of 18 institutes from 12 European countries analysed an extract of the same water sample collected from the River Danube with either one or both of liquid and gas chromatography coupled with mass spectrometry detection. This article focuses mainly on the use of high resolution screening techniques with target, suspect, and non-target workflows to identify substances in environmental samples. Specific examples are given to emphasise major challenges including isobaric and co-eluting substances, dependence on target and suspect lists, formula assignment, the use of retention information, and the confidence of identification. Approaches and methods applicable to unit resolution data are also discussed. Although most substances were identified using high resolution data with target and suspect-screening approaches, some participants proposed tentative non-target identifications. This comprehensive dataset revealed that non-target analytical techniques are already substantially harmonised between the participants, but the data processing remains time-consuming. Although the objective of a "fully-automated identification workflow" remains elusive in the short term, important steps in this direction have been taken, exemplified by the growing popularity of suspect screening approaches. Major recommendations to improve non-target screening include better integration and connection of desired features into software packages, the exchange of target and suspect lists, and the contribution of more spectra from standard substances into (openly accessible) databases. Graphical Abstract Matrix of identification approach versus identification confidence.
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                Author and article information

                Contributors
                kmyleung@hku.hk
                Journal
                Environ Toxicol Chem
                Environ. Toxicol. Chem
                10.1002/(ISSN)1552-8618
                ETC
                Environmental Toxicology and Chemistry
                John Wiley and Sons Inc. (Hoboken )
                0730-7268
                1552-8618
                20 July 2020
                August 2020
                : 39
                : 8 ( doiID: 10.1002/etc.v39.8 )
                : 1485-1505
                Affiliations
                [ 1 ] Swire Institute of Marine Science and School of Biological Sciences University of Hong Kong Pokfulam Hong Kong China
                [ 2 ] State Key Laboratory of Marine Pollution and Department of Chemistry City University of Hong Kong Kowloon Hong Kong China
                [ 3 ] School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health Jinan University Guangzhou China
                [ 4 ] Seoul National University Seoul Korea
                [ 5 ] School of the Environment Nanjing University Nanjing China
                [ 6 ] Hydrobiology Brisbane Queensland Australia
                [ 7 ] Open University of Hong Kong Hong Kong China
                [ 8 ] PETRONAS Kuala Lumpur Malaysia
                [ 9 ] Konkuk University Seoul Korea
                [ 10 ] Baylor University Waco Texas USA
                [ 11 ] International Copper Association Washington DC USA
                [ 12 ] Nanyang Technological University Singapore
                [ 13 ] University of Malaysia Terengganu Malaysia
                [ 14 ] Loyola University Chicago Illinois USA
                [ 15 ] Supervising Scientist Branch Canberra Australian Capital Territory Australia
                [ 16 ] Khon Kaen University Khon Kaen Thailand
                [ 17 ] Kunsan National University Gunsan Korea
                [ 18 ] National University of Singapore Singapore
                [ 19 ] Universiti Putra Serdang Malaysia
                [ 20 ] Corteva Agriscience Geneva Switzerland
                [ 21 ] Proctor and Gamble Singapore
                [ 22 ] National Institute of Advanced Industrial Science and Technology Tokyo Japan
                [ 23 ] International Copper Association–Asia Shanghai China
                [ 24 ] College of Fisheries and Ocean Sciences University of the Philippines Visayas Iloilo City Philippines
                [ 25 ] Bandung Institute of Technology Bandung Indonesia
                [ 26 ] Department of Microbiology Faculty of Science, University of Kelaniya Kelaniya Sri Lanka
                [ 27 ] Universitas Brawijaya Malan Indonesia
                [ 28 ] University of Dhaka Dhaka Bangladesh
                [ 29 ] University of the Philippines Los Baños Los Baños Philippines
                [ 30 ] US Environmental Protection Agency Washington DC
                [ 31 ] University of York York United Kingdom
                [ 32 ] World Maritime University Malmo Sweden
                Author notes
                [*] [* ]Address correspondence to kmyleung@ 123456hku.hk

                Author information
                http://orcid.org/0000-0002-2164-4281
                http://orcid.org/0000-0002-4006-8339
                http://orcid.org/0000-0001-7343-2902
                http://orcid.org/0000-0002-0193-1929
                http://orcid.org/0000-0001-8113-2651
                http://orcid.org/0000-0001-6337-0947
                http://orcid.org/0000-0003-3476-7018
                http://orcid.org/0000-0003-3823-7516
                http://orcid.org/0000-0002-6277-9852
                Article
                ETC4788
                10.1002/etc.4788
                7496081
                32474951
                3c2eec64-da78-4b8b-bdf4-b5f723cbeb9b
                © 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 11 March 2020
                : 03 April 2020
                : 22 May 2020
                Page count
                Figures: 1, Tables: 2, Pages: 21, Words: 17496
                Funding
                Funded by: T. and D. Robert
                Award ID: NA
                Funded by: State Key Laboratory of Marine Pollution, City University of Hong Kong
                Award ID: NA
                Funded by: Baylor University , open-funder-registry 10.13039/100007492;
                Award ID: NA
                Funded by: University of Hong Kong , open-funder-registry 10.13039/501100003803;
                Award ID: NA
                Funded by: U.S. Environmental Protection Agency , open-funder-registry 10.13039/100000139;
                Award ID: NA
                Funded by: University of York , open-funder-registry 10.13039/100009001;
                Award ID: NA
                Categories
                Critical Review
                Critical Review
                Custom metadata
                2.0
                August 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.0 mode:remove_FC converted:11.09.2020

                Environmental chemistry
                environmental chemistry,environmental toxicology,hazard/risk assessment,biomonitoring,climate change

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