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      Nothnagel Syndrome.

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          Abstract

          The internist Hermann Nothnagel (1841-1905) took a special interest in the cerebellum. In an early experimental study on rabbits conducted in 1876, he demonstrated the involvement of the vermis in the pathophysiology of motor ataxia. Between 1879 and 1889, he reported four cases of tectal tumors that clinically manifested with bilateral ophthalmoplegia and unilateral gait ataxia, culminating in the Cerebellar Classic highlighted here. Nothnagel attributed this clinical syndrome to lesions of the colliculi ("quadrigeminal bodies") and compression of the nuclei of the third cranial nerves, but also left open the possibility of the involvement of neighboring structures, such as the cerebellar vermis. Today, the ataxic component of Nothnagel syndrome is explained by a dorsal midbrain abnormality of either neoplastic or vascular origin, involving the superior cerebellar peduncles, besides the oculomotor nerves.

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          Author and article information

          Journal
          Cerebellum
          Cerebellum (London, England)
          Springer Science and Business Media LLC
          1473-4230
          1473-4222
          Aug 2023
          : 22
          : 4
          Affiliations
          [1 ] Sector of Experimental Cognitive Psychology, Department of Psychology, Faculty of Philosophy, Aristotelian University, 54124, Thessaloniki, Greece. triarhou@auth.gr.
          [2 ] Unité des Ataxies Cérébelleuses, CHU-Charleroi, Charleroi, Belgium.
          [3 ] Service des Neurosciences, University of Mons, Mons, Belgium.
          Article
          10.1007/s12311-022-01437-w
          10.1007/s12311-022-01437-w
          35817948
          2a0c99f3-6cac-468d-8ec4-043631ac8fb7
          History

          Superior cerebellar peduncle,Ophthalmoplegia,Gait ataxia,Claude syndrome,Third cranial nerve,Tectum mesencephali,Parinaud syndrome

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