Mike Khan: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Writing – original draftRole: Writing – review & editing
Jerome S. Harms: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – review
& editing
Yiping Liu: Role: Investigation
Jens Eickhoff:
ORCID: https://orcid.org/0000-0003-0525-6462
Role: Formal analysisRole: InvestigationRole: Methodology
Jin Wen Tan:
ORCID: https://orcid.org/0000-0001-6215-0520
Role: Investigation
Tony Hu:
ORCID: https://orcid.org/0000-0003-0376-6311
Role: Investigation
Fengwei Cai: Role: Investigation
Erika Guimaraes: Role: Investigation
Sergio Costa Oliveira: Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Writing – review
& editing
Richard Dahl: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Yong Cheng: Role: Investigation
Delia Gutman:
ORCID: https://orcid.org/0000-0001-7683-6785
Role: Investigation
Glen N. Barber: Role: ConceptualizationRole: Funding acquisition
Gary A. Splitter: Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
Judith A. Smith:
ORCID: https://orcid.org/0000-0003-4158-8253
Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Writing – review
& editing
Mary O'Riordan: Role: Editor
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Journal ID (pmc): plospath
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
27
October
2020
Publication date Collection:
October
2020
Volume: 16
Issue: 10
Electronic Location Identifier: e1009020
Affiliations
[1
]
Cellular and Molecular Pathology Training Program, University of Wisconsin-Madison,
Madison, Wisconsin, United States of America
[2
]
Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United
States of America
[3
]
Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison,
Madison, Wisconsin, United States of America
[4
]
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade
Federal de Minas Gerais, Belo Horizonte-Minas Gerais, Brazil
[5
]
Programa de Pós-Graduação em Genética, Instituto de Ciências Biológicas, Universidade
Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
[6
]
Department of Microbiology and Immunology, Indiana University School of Medicine,
South Bend, Indiana, United States of America
[7
]
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana,
United States of America
[8
]
Department of Cell Biology, University of Miami, Miami, Florida, United States of
America
[9
]
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison,
Wisconsin, United States of America
[10
]
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison,
Madison, Wisconsin, United States of America
University of Michigan Medical School, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PPATHOGENS-D-20-00042
DOI: 10.1371/journal.ppat.1009020
PMC ID: 7647118
PubMed ID: 33108406
SO-VID: 0eb74c44-d56a-4aae-8a32-1f2fcc503d55
Copyright © © 2020 Khan et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
M.K. received the F31 AI115931 National Institutes of Health training award. S.C.O.
received the NIH R01 AI116453 National Institutes of Health award. G.A.S. received
the NIH R01 AI073558 National Institutes of Health award. R.D. received NIH R01 DK109051
National Institutes of Health award. J.A.S. was a multi-PI on NIH R01 AI073558. The
funders had no role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Brucella
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Bacterial Pathogens
Subject:
Brucella
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Bacterial Pathogens
Subject:
Brucella
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
RNA
Subject:
Non-coding RNA
Subject:
Natural antisense transcripts
Subject:
MicroRNAs
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Gene expression
Subject:
Gene regulation
Subject:
MicroRNAs
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Transfection
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Transfection
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Immune Receptors
Subject:
Toll-like Receptors
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Immune Receptors
Subject:
Toll-like Receptors
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Immune Receptors
Subject:
Toll-like Receptors
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Signal Transduction
Subject:
Immune Receptors
Subject:
Toll-like Receptors
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Interferons
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Bacteriology
Subject:
Bacterial Physiology
Subject:
Secretion Systems
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Microbial Physiology
Subject:
Bacterial Physiology
Subject:
Secretion Systems
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Virulence Factors
Subject:
Secretion Systems
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression