Sir,
Epidemic diseases affecting substantial population of the world is not new and the
list of epidemics and pandemics are reported as early as 429 BC.[1] A pandemic is
defined as “an epidemic occurring worldwide, or over a wide area, crossing international
boundaries and usually affecting a large population.” In late December 2019, China
reported cases of patients with pneumonia of unknown etiology which was classified
as epidemic and later upgraded as pandemic. The virus was previously known as “2019
novel coronavirus” and the disease it caused is named as coronavirus disease (COVID-19)
which appears to be of zoonotic origin.[2] The World Health Organization (WHO) raised
a global alert on the need of containment, surveillance, detection, isolation, and
contact tracing.[3] Countries across the world responded to this unprecedented pandemic
by harsh containment measures. The Indian government responded with the invocation
of Disaster Management Act and Epidemic Diseases Act; closing the entire establishment
except essential services on March 24, 2020, which was termed as lockdown.
The outbreak of COVID-19 has provided many fold challenges for Radiation Oncology
Department worldwide as the treatment is scheduled over weeks (typically 5–7 weeks).
It was interesting to study the reported radiotherapy precautions from the Chinese
experience,[4
5] where the outbreak was severe. Personnel-protective equipment (PPE) was provided
to the selected staffs of Radiation Oncology Department according to hospital infection
control policy for droplet precautions as recommended by the WHO.[6] Patients were
required to wear a surgical mask for the entire duration of the radiation oncology
procedure, and the mask was especially required for head and neck patients. Italian
experiences have also been reported where the prevention of infection spread has been
given sufficient weightage, but infection control measures for radiotherapy accessories
have not been discussed.[7] The impacts of corona pandemic have also been reported
from the USA and Europe.[8
9] The USA report discussed the various measures adopted for controling the infection
while the report of Europe is summary of a questionnaire-based survey conducted to
know the influence of the pandemic on the practice of radiotherapy. However, the specific
information pertaining to change in the practice for quality assurance (QA), treatment
planning, dosimetry, overall workflow for existing and new patients, and policy for
managing the gap in the treatment are missing from these publications. It is true
that the overall philosophy of radiotherapy practice will remain the same, but technical
and operational aspects of the Radiation Oncology Department need to be revised for
controling the infection to patient, public, staff, equipment, and the environment.
The unfolding events warranted our hospital administration to respond to any eventual
emergency. Since many cancer patients are already immunocompromised, the radiation
oncology department required to revise the standard operating procedure (SOP) for
the continuation of treatment under the COVID-19 situation. Being an international
and national accredited hospital, the protocols and guidelines are in place with regard
to general infection control in our hospital. However, the unprecedented situation
of this pandemic warranted formulation of specific operational guidelines for radiation
oncology practice based on the principle of the prevention of COVID-19 infection and
lockdown situation. A committee of the radiation oncology department discussed the
issue in detail and consensus was arrived to formulate the guidelines covering complete
workflow, including technical and administrative aspects for the inclusion in SOP.
Specifically, it was decided to revise the SOP of the radiation oncology department
by including components on (i) Staff education and safety, (ii) Patient education
and safety, (iii) Safe handling of radiotherapy accessories, and (iv) QA/quality control
(QC) schedules. As the revision in SOP is linked with equipment, personnel and practices,
a brief introduction of the infrastructure of radiation oncology department of the
hospital will add clarity in subsequent discussions.
Our radiation oncology department is equipped with flattening filter free (FFF) TrueBeam
STx Linear accelerator (Varian Medical System, USA) having photon energies of 6, 10,
15, 6FFF, and 10FFF MV and electron energies of 6, 9, 12, and 15 MeV. The department
has active stereotactic treatment program aided by HD120 multileaf collimator (MLC)
and ExacTrac X-ray monitoring system (BrainLab AG, Germany) for noncoplanar imaging.
Brachytherapy treatments are performed with 18 channel microSelectron high-dose rate
(HDR) (Elekta AB, Sweden). On an average, 50–55 patients receive treatment daily.
Staffs of radiation oncology department includes 3 full-time radiation oncologists,
2 medical physicists (MPs), 4 radiation therapy technologists (RTTs), 2 nurses, and
2 patient attainders. While formulating the guidelines for inclusion in SOP, the recommendations
of individual, institutional, and professional societies were given due considerations.[4
5
6
7
8
9
10
11] Following are the brief descriptions of the additional components included in
the SOP of the radiation oncology department and their implementation aspects:
Since COVID-19 has incubation period of 5–14 days,[12] it was recommended to use PPE
while treating patients who may or may not be symptomatic. National and international
recommendations are followed regarding the use of mask and PPE during the treatment
and disposal thereafter.[13
14
15] As the primary mode of COVID-19 transmission is through droplets, universal precaution
for droplet transmission was identified and the staffs of the department were educated
accordingly (hand hygiene; respiratory hygiene; avoid touching eyes, nose and mouth;
and judicious use of PPE). In addition, staffs were specially advised to have minimal
interaction with the patients. Grouping and rotation of staffs without affecting the
efficiency of the department were also incorporated in the SOP. For example, in place
of 2 MPs and 4 RTTs, 1 MP, and 2 RTTs will only be available at a time. Further as
a matter of policy, treatment by hypofractionation in case of new patients, wherever
clinically applicable, is given preference over long duration fractionated treatments.
Unless otherwise necessary, brachytherapy treatments (both low and HDRs; temporary
or permanent implants) should not be prescribed as it requires long duration dealing
with the patients.
The patients were educated for COVID-19 infection mode and infection control measures.
Seating arrangement in the waiting area was made to have at least 1 m distance between
two patients. The chairs are frequently cleaned with 5% sodium hypochlorite solution.
The major source of infection for patients or staff is through contact with radiotherapy
accessories. Since most of the accessories are reused for patients over treatment
period, frequent cleaning and disinfection were important to control cross contamination.
In general, thermoplastic masks are used for the treatment site of brain and head
and neck cancers. The masks in use are equipped with nonstick surface coating with
antibacterial properties. Guidelines from manufacturer were considered and suggestions
from infection control team of the hospital were incorporated (e.g., disinfect the
masks before use with alcohol-based disinfectant, wipe the inner and outer surface
with sufficient amount of solution, and disinfect the mask after use with 0.5% sodium
hypochlorite solution). Head and neck patients or patients having excess mucous secretion
were required to wear either a surgical or N95 mask for the entire duration of the
radiation oncology procedure (starting from imaging to treatment delivery).
Head support, base plate, armrest, breast board, and any other accessory are wiped
after every use with 70% alcohol-based disinfectant. Vacuum cushions were used for
the treatment site of thorax, breast, abdomen, and pelvis treatment sites. Each cushion
contains small polystyrene spheres surrounded by a durable polyurethane coated nylon
fabric. Since these cushions may not directly come into droplet contact, large size
paper towel were placed over the cushions. The treatment couch was disinfected after
each use with 0.5% sodium hypochlorite solution.
QA/QC of the radiotherapy equipment and accessories is an important component of quality
radiotherapy practice. Our QC programme for the accelerator is based on AAPM TG142[16]
and IAEA TRS398[17] recommendations. However, the list of QA test parameters recommended
by AAPM TG142 is quite long requiring revision in existing QA schedule for this period
without compromising the quality of performance. This revision in QA schedule is required
because of the reduction in human resources due to grouping and rotation. A thorough
study of the past performance of the accelerator was carried out and performance results
of last 600 measurements were analyzed. Table 1 presents the list of test parameters
and their maximum deviation from the baseline value in the last 600 measurements.
Table 1
Test parameters of medical electron linear accelerator and their maximum deviation
in last 600 measurements
Test parameters
Maximum deviation from baseline
Output constancy (X-rays) (%)
3.0
Beam uniformity (%)
2.8
Jaw position indicators (mm)
0.1
MLC leaf position accuracy (mm)
0.14
Gantry/collimator indicator (degree)
0.1
Shift in isocenter (mm)
0.37
kV/MV isocenter displacement (mm)
0.16
Couch displacement in lateral/longitudinal/vertical (mm)
0.30
MLC: Multileaf collimator
It is observed from this table that the deviations are well within the limit all the
time which provided us the confidence that even if these tests were eliminated from
the QA schedule for a limited period, it will not affect the performance of the accelerator.
Accordingly, QA schedule of the accelerator was revised [Table 2] to minimize the
resources required for conducting QA/QC on periodic basis.
Table 2
Revised quality assurance/quality control schedule for medical electron linear accelerator
along with recommended tolerance, test frequency, and personnel required
Test parameters
Method/instrument
Prescribed tolerance
Recommended tolerance
Test frequency
Personnel required
Dosimetry
X-ray output constancy
MPC[18]
3%
3% (5% AL)
Daily
1
Electron output constancy
MPC
3%
3% (5% AL)
Daily
1
Reference dosimetry
Ion chamber and water phantom
3%
3%
Weekly
2
X-ray profile constancy
MPC
3%
3% (5% AL)
Monthly
1
Electron profile constancy
MPC
3%
3% (5% AL)
Monthly
1
Mechanical
Laser localization
MPC phantom and couch value
1.5 mm
2 mm (3 mm AL)
Daily
1
ODI
Couch value indicator (vertical=0)
2 mm
2 mm (3 mm AL)
Daily
1
Collimator size indicator
Radiological image based
2 mm
4 mm
Daily
1
Safety
Door interlock
During MPC
Functional
Functional
Daily
1
Door closing safety
During MPC
Functional
Functional
Daily
1
Audiovisual monitors
During MPC
Functional
Functional
Daily
1
Beam on indicator
During MPC
Functional
Functional
Daily
1
Laser guard interlock test
MPC Phantom
Functional
Functional
Weekly
1
Respiratory gating
-
Functional
Functional
Patient based
1
MLC
Skip, if patient specific QA is carried out (5%/5 mm AL)
1
Imaging
Collision test
Software restriction
Functional
Functional
Daily/skip
1
Image quality
Perform calibration if image quality is degraded
1
ODI: Optical distance indicator, MPC: Machine performance check, which is an automated
and integrated image-based tool for the verification of beam and geometric performance
of the TrueBeam, AL: Action level, QA: Quality assurance
Some of the monthly tests recommended in AAPM TG142 report were skipped as most of
our treatments are IMRT/ VMAT. The tolerance levels for laser and optical distance
indicator are relaxed because majority of patients were treated under image guidance.
MLC QA has been reduced because pretreatment QA for IMRT/VMAT patients is the mandatory
requirement as quality service policy of the department. The pretreatment QA is staggered
over a week and any failure is considered as potential deterioration of MLC performance.
Image quality tests were skipped till the images are suitable for localization. The
method of quadratic summation to set the tolerance values to achieve an overall uncertainty
of 5% and 5 mm was further refined in AAPM TG142 report. We hope to achieve the tolerance
of 5% and 5 mm with recommended tests and frequency. AAPM TG142 allows flexibility
in the QA/QC program considering the quality, costs, equipment condition, available
test equipment, and institutional needs. Daily/weekly tests can affect dose to the
patient and were carefully tested maintaining minimum standard. Monthly tests include
those parameters that have lower likelihood of changing over a month, hence were carefully
chosen considering likelihood that this pandemic may be over in next few months. The
reference dose measurement and patient specific QA are directly linked with precision
and accuracy of treatment delivery (may affect treatment outcome drastically) and
hence their measurement frequency were left unchanged. However, care should be taken
that minimum personnel are involved, and the safe infection control policy is adhered
to. Action levels are specifically mentioned keeping in mind that rectification of
the fault may not be possible immediately as engineer movements are also restricted.
Hence, we may need to continue treatment even though specific test breaches threshold
tolerance and would be mitigated by increasing planning target volume and planning
risk volume margins. We have tried to balance minimum standards of QA with infection
control aspects. Notable limitation in the QA schedule is the MPC[18] based tests
which is exclusive feature of TrueBeam accelerator.
Since our hospital is a multi-specialty healthcare unit with national and international
accreditation, we have infection control policy in place. This provision may not be
available in stand-alone centers, and hence, the operational procedures outlined here
may serve the purpose to mitigate the operational challenges faced with continuation
of radiotherapy treatment in such centers. Further, the operational procedures and
QA schedules discussed in this letter are consistent with droplet precautions policy
which has been discussed in various reports.[4
5
6
7
8
9
10
11] However, we have made an effort to make COVID-19 specific guidelines following
the radiation protection principle of time, distance, and shielding. Accordingly,
the message is spend minimum time by cutting down nonessential physical meetings/interactions,
adhere to social distancing, and use PPE judiciously.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.