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      Large articulations do not increase wear rates of thin second-generation highly cross-linked polyethylene liners at ten years

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          Abstract

          Aims

          Radiostereometric analysis (RSA) is the most accurate radiological method to measure in vivo wear of highly cross-linked polyethylene (XLPE) acetabular components. We have previously reported very low wear rates for a sequentially irradiated and annealed X3 XLPE liner (Stryker Orthopaedics, USA) when used in conjunction with a 32 mm femoral heads at ten-year follow-up. Only two studies have reported the long-term wear rate of X3 liners used in conjunction with larger heads using plain radiographs which have poor sensitivity. The aim of this study was to measure the ten-year wear of thin X3 XLPE liners against larger 36 or 40 mm articulations with RSA.

          Methods

          We prospectively reviewed 19 patients who underwent primary cementless THA with the XLPE acetabular liner (X3) and a 36 or 40 mm femoral head with a resultant liner thickness of at least 5.8 mm. RSA radiographs at one week, six months, and one, two, five, and ten years postoperatively and femoral head penetration within the acetabular component were measured with UmRSA software. Of the initial 19 patients, 12 were available at the ten-year time point.

          Results

          The median proximal, 2D, and 3D wear rates calculated between one and ten years were all less than 0.005 mm/year, with no patient recording a proximal wear rate of more than 0.021 mm/year. Importantly, there was no increase in the wear rate between five and ten years.

          Conclusion

          The very low wear rate of X3 XLPE liners with larger articulations remains encouraging for the future clinical performance of this material.

          Cite this article: Bone Jt Open 2023;4(11):839–845.

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          Most cited references37

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          A literature review of the association between wear rate and osteolysis in total hip arthroplasty.

          The establishment of a polyethylene wear rate threshold for the development of osteolysis at the hip would allow surgeons to identify patients at risk for osteolysis and to implement selective, more frequent follow-up. We reviewed publications that met certain criteria for wear and osteolysis measurement. Based on this review, the incidence of osteolysis increases as the rate of wear increases. The literature indicates that osteolysis rarely is observed at a wear rate of <0.1 mm/y. We suggest that a practical wear rate threshold of 0.05 mm/y would eliminate osteolysis. This wear threshold suggests that the new cross-linked polyethylenes would reduce osteolysis, provided that in vivo wear rates mirror those observed in vitro. To facilitate future comparison of published data, we suggest that longitudinal wear studies adopt consistent edge detection-based wear measurement techniques and uniform osteolytic lesion classification and measurement schema. Copyright 2002, Elsevier Science (USA). All rights reserved.
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            Effect of femoral head diameter and operative approach on risk of dislocation after primary total hip arthroplasty.

            It has been postulated that use of a larger femoral head could reduce the risk of dislocation after total hip arthroplasty, but only limited clinical data have been presented as proof of this hypothesis. From 1969 to 1999, 21,047 primary total hip arthroplasties with varying femoral head sizes were performed at one institution. Patients routinely were followed at defined intervals and were specifically queried about dislocation. The operative approach was anterolateral in 9155 arthroplasties, posterolateral in 3646, and transtrochanteric in 8246. The femoral head diameter was 22 mm in 8691 of the procedures, 28 mm in 8797, and 32 mm in 3559. One or more dislocations occurred in 868 of the 21,047 hips. The cumulative risk of first-time dislocation was 2.2% at one year, 3.0% at five years, 3.8% at ten years, and 6.0% at twenty years. The cumulative ten-year rate of dislocation was 3.1% following anterolateral approaches, 3.4% following transtrochanteric approaches, and 6.9% following posterolateral approaches. The cumulative ten-year rate of dislocation was 3.8% for 22-mm-diameter femoral heads, 3.0% for 28-mm heads, and 2.4% for 32-mm heads in hips treated with an anterolateral approach; 3.5% for 22-mm heads, 3.5% for 28-mm heads, and 2.8% for 32-mm heads in hips treated with a transtrochanteric approach; and 12.1% for 22-mm heads, 6.9% for 28-mm heads, and 3.8% for 32-mm heads in hips treated with a posterolateral approach. Multivariate analysis showed the relative risk of dislocation to be 1.7 for 22-mm compared with 32-mm heads and 1.3 for 28-mm compared with 32-mm heads. In total hip arthroplasty, a larger femoral head diameter was associated with a lower long-term cumulative risk of dislocation. The femoral head diameter had an effect in association with all operative approaches, but the effect was greatest in association with the posterolateral approach.
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              Large femoral heads decrease the incidence of dislocation after total hip arthroplasty: a randomized controlled trial.

              The use of larger femoral heads has been proposed to reduce the risk of dislocation after total hip arthroplasty, but there is a lack of evidence to support this proposal. The aim of this multicenter randomized controlled trial was to determine whether the incidence of dislocation one year after total hip arthroplasty is significantly lower in association with the use of a 36-mm femoral head articulation as compared with a 28-mm articulation. Six hundred and forty-four middle-aged and elderly patients undergoing primary or revision arthroplasty were randomized intraoperatively to receive either a 36 or 28-mm metal femoral head on highly cross-linked polyethylene. Patients who were at high risk of dislocation (including those with dementia and neuromuscular disease) and those undergoing revision for the treatment of recurrent hip dislocation or infection were excluded. Patients were stratified according to other potential risk factors for dislocation, including diagnosis and age. Diagnosis of hip dislocation required confirmation by a physician and radiographic evidence of a dislocation. Overall, at one year of follow-up, hips with a 36-mm femoral head articulation had a significantly lower incidence of dislocation than did those with a 28-mm articulation (1.3% [four of 299] compared with 5.4% [seventeen of 316]; difference, 4.1% [95% confidence interval, 1.2% to 7.2%]) when controlling for the type of procedure (primary or revision) (p = 0.012). The incidence of dislocation following primary arthroplasty was also significantly lower for hips with a 36-mm femoral head articulation than for those with a 28-mm articulation (0.8% [two of 258] compared with 4.4% [twelve of 275]; difference, 3.6% [95% confidence interval, 0.9% to 6.8%]) (p = 0.024). The incidence of dislocation following revision arthroplasty was 4.9% (two of forty-one) for hips with a 36-mm articulation and 12.2% (five of forty-one) for hips with a 28-mm articulation; this difference was not significant with the relatively small sample size of the revision group (difference, 7.3% [95% confidence interval, -5.9% to 21.1%]) (p = 0.273). Compared with a 28-mm femoral head articulation, a larger 36-mm articulation resulted in a significantly decreased incidence of dislocation in the first year following primary total hip arthroplasty. However, before a 36-mm metal-on-highly cross-linked polyethylene articulation is widely recommended, the incidence of late dislocation, wear, periprosthetic osteolysis, and liner fracture should be established.
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                Author and article information

                Contributors
                Role: Senior Medical Scientist
                Role: Medical Scientist
                Role: Honours Student
                Role: Orthopaedic Surgeon
                Journal
                Bone Jt Open
                Bone Jt Open
                BJO
                Bone & Joint Open
                The British Editorial Society of Bone & Joint Surgery (London )
                2633-1462
                6 November 2023
                November 2023
                : 4
                : 11
                : 839-845
                Affiliations
                [1 ] org-divisionCentre for Orthopaedic and Trauma Research, The University of Adelaide and Department of Orthopaedics and Trauma, Royal Adelaide Hospital , Adelaide, South Australia
                [2 ] org-divisionCentre for Orthopaedic and Trauma Research, The University of Adelaide , Adelaide, South Australia
                [3 ] org-divisionWakefield Orthopaedic Clinic , Adelaide, Australia
                Author notes
                Correspondence should be sent to Stuart A. Callary. E-mail: stuart.callary@ 123456adelaide.edu.au
                Author information
                https://orcid.org/0000-0002-2892-5238
                https://orcid.org/0000-0002-1572-9529
                Article
                BJO-2023-0124.R1
                10.1302/2633-1462.411.BJO-2023-0124.R1
                10625862
                05f1494f-e7e6-4c34-bb54-69dfe7f1398f
                © 2023 Callary et al.

                Open Access This article is distributed under the terms of the Creative Commons Attributions (CC BY 4.0) licence ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original author and source are credited.

                History
                Funding
                Funded by: org-divisionThe Hospital Research Foundation Group, doi https://doi.org/10.13039/100009727;
                Award ID: EMCR-004
                Award Recipient :
                Categories
                Hip
                Hip
                Arthroplasty
                Reverse Hybrid
                Hip, hip
                bj1763, Basic science
                bj4445, Diagnostic and analytical techniques in orthopaedics
                bj11386, Orthopaedic devices
                bj731, Anatomy
                bj11416, Orthopaedic treatments
                bj1268, Arthroplasty
                bj6858, Hip
                bj6813, Highly cross-linked polyethylene
                bj5624, Femoral head
                bj13717, Radiostereometric analysis
                bj127, Acetabular components
                bj12522, Plain radiography
                bj152, Acetabular liners
                bj2966, Cementless total hip arthroplasty
                bj13687, Radiographic imaging
                bj13177, Primary total hip arthroplasty
                Custom metadata
                2.0
                $2.00
                Calvary Adelaide Hospital, Australia
                Hip
                D. G. Campbell received, during the study period, funding from Stryker Australia. However, the company was not involved in the planning of the experiment or data collection, analyses, interpretation or writing of the manuscript. S. A. Callary declares being co-investigator of a project grant from Zimmer Biomet, which is unrelated to this article. D. K. Sharma reports project support (paid to institution) from Synergia Life Sciences, which is also unrelated.

                wear,radiostereometric analysis,total hip arthroplasty,implant design,cross-linked polyethylene,bearing surface,highly cross-linked polyethylene,femoral heads,radiostereometric analysis (rsa),acetabular components,plain radiographs,acetabular liner,cementless tha,radiographs,hips,primary tha

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