Clinical impact of programmed cell death ligand 1 expression in colorectal cancer.

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Abstract

Programmed cell death 1 (PD-1) receptor triggering by PD ligand 1 (PD-L1) inhibits T cell activation. PD-L1 expression was detected in different malignancies and associated with poor prognosis. Therapeutic antibodies inhibiting PD-1/PD-L1 interaction have been developed.

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Journal

Journal ID (iso-abbrev): Eur J Cancer

Title: European journal of cancer (Oxford, England : 1990)

Publisher: Elsevier BV

ISSN (Electronic): 1879-0852

ISSN (Print): 0959-8049

Publication date (Electronic): Jun 2013

Volume: 49

Issue: 9

Affiliations

[1 ] Department of Surgery, University Hospital of Basel, Switzerland; Institute for Surgical Research and Hospital Management ICFS, Department of Biomedicine, University of Basel, Switzerland. Electronic address: rdroeser@uhbs.ch.

[2 ] Department of Surgery, University Hospital of Basel, Switzerland; Institute for Surgical Research and Hospital Management ICFS, Department of Biomedicine, University of Basel, Switzerland.

[3 ] Department of Surgery, University Hospital of Basel, Switzerland.

[4 ] Institute of Pathology, University of Bern, Switzerland.

[5 ] Institute of Pathology, University of Basel, Switzerland.

[6 ] Department of Surgery, Ospedale Regionale di Lugano, Switzerland.

[7 ] Department of Surgery, Kantonsspital Olten, Switzerland.

[8 ] Institute for Surgical Research and Hospital Management ICFS, Department of Biomedicine, University of Basel, Switzerland.

[9 ] Institute of Translational Pharmacology, National Council Research, Rome, Italy.

Article

Publisher Item ID: S0959-8049(13)00123-8

DOI: 10.1016/j.ejca.2013.02.015

PubMed ID: 23478000

SO-VID: 0356eff3-bfd7-4e0d-bb0a-b88cbf693d45

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