Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

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Abstract

Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.

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Most cited references 70

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Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal.

J. Gao, B. A. Aksoy, U Dogrusoz … (2015)

The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.

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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.

Ethan Cerami, Jianjiong Gao, Ugur Dogrusoz … (2012)

The cBio Cancer Genomics Portal (http://cbioportal.org) is an open-access resource for interactive exploration of multidimensional cancer genomics data sets, currently providing access to data from more than 5,000 tumor samples from 20 cancer studies. The cBio Cancer Genomics Portal significantly lowers the barriers between complex genomic data and cancer researchers who want rapid, intuitive, and high-quality access to molecular profiles and clinical attributes from large-scale cancer genomics projects and empowers researchers to translate these rich data sets into biologic insights and clinical applications. © 2012 AACR.

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Is Open Access

METAL: fast and efficient meta-analysis of genomewide association scans

Cristen Willer, Yun Li, Gonçalo R Abecasis (2010)

Summary: METAL provides a computationally efficient tool for meta-analysis of genome-wide association scans, which is a commonly used approach for improving power complex traits gene mapping studies. METAL provides a rich scripting interface and implements efficient memory management to allow analyses of very large data sets and to support a variety of input file formats. Availability and implementation: METAL, including source code, documentation, examples, and executables, is available at http://www.sph.umich.edu/csg/abecasis/metal/ Contact: goncalo@umich.edu

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Author and article information

Journal

Journal ID (iso-abbrev): Nat. Genet.

Title: Nature genetics

Publisher: Springer Nature

ISSN (Electronic): 1546-1718

ISSN (Print): 1061-4036

Publication date (Electronic): Feb 2015

Volume: 47

Issue: 2

Affiliations

[1 ] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

[2 ] Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.

[3 ] Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.

[4 ] Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

[5 ] Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California, USA.

[6 ] 1] Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA. [2] Knight Cancer Institute, Portland, Oregon, USA.

[7 ] Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

[8 ] 1] Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. [2] Center for Cell-Based Therapy, Monte Alegre, Ribeirão Preto, Brazil. [3] Center for Integrative Systems Biology, Monte Alegre, Ribeirão Preto, Brazil.

[9 ] 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. [2] Department of Urology, University of Southern California, Los Angeles, California, USA.

[10 ] Department of Genomics and Genome Sciences, Case Western Reserve University Medical School, Cleveland, Ohio, USA.

[11 ] Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.

[12 ] Department of Epidemiology, Columbia University, New York, New York, USA.

[13 ] Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

[14 ] Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.

[15 ] 1] Department of Molecular and Regenerative Medicine, Hematology, Oncology and Transfusion Medical Center, Vilinius University Hospital Santariskiu Clinics, Vilnius, Lithuania, Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania. [2] State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.

[16 ] Department of Genetics, University of Pretoria, Pretoria, South Africa.

[17 ] Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.

[18 ] Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

[19 ] Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

[20 ] Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

[21 ] 1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2] Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.

[22 ] 1] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [2] Human Genotyping Unit (CEGEN), Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [3] Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.

[23 ] 1] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [2] Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.

[24 ] Maricopa Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California, USA.

[25 ] Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California, USA.

[26 ] Cook County Health and Hospital System, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California, USA.

[27 ] Fondazione Istituto FIRC (Italian Foundation for Cancer Research) di Oncologia Molecolare (IFOM), Milan, Italy.

[28 ] 1] Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy. [2] Cogentech Cancer Genetic Test Laboratory, Milan, Italy.

[29 ] Division of Experimental Oncology, CRO (Centro di Riferimento Oncologico) Aviano National Cancer Institute, Aviano, Italy.

[30 ] Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy.

[31 ] Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico (Italian Research Hospital)) Istituto Nazionale Tumori (INT), Milan, Italy.

[32 ] Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy.

[33 ] Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.

[34 ] Department of Molecular Medicine, University La Sapienza, Rome, Italy.

[35 ] Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece.

[36 ] Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

[37 ] Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

[38 ] 1] Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany. [2] Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany. [3] Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. [4] On behalf of the German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC).

[39 ] Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

[40 ] Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.

[41 ] Institute of Human Genetics, University Heidelberg, Heidelberg, Germany.

[42 ] 1] INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France. [2] Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon-Centre Léon Bérard, Lyon, France.

[43 ] INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France.

[44 ] 1] Institut Curie, Department of Tumour Biology, Paris, France. [2] Institut Curie, INSERM U830, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

[45 ] Center for Medical Genetics, Ghent University, Ghent, Belgium.

[46 ] Australia New Zealand Gynecologic Oncology Group (ANZGOG) and Familial Cancer Service, Westmead Hosptial, Sydney, New South Wales, Australia.

[47 ] Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, Illinois, USA.

[48 ] Gynecologic Oncology Group, Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, USA.

[49 ] James Cancer Center, Ohio State University, Columbus, Ohio, USA.

[50 ] Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain.

[51 ] Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland.

[52 ] Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

[53 ] Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands.

[54 ] Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

[55 ] Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands.

[56 ] Latvian Biomedical Research and Study Centre, Riga, Latvia.

[57 ] Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

[58 ] Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.

[59 ] Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

[60 ] Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada.

[61 ] N.N. Petrov Institute of Oncology, St. Petersburg, Russia.

[62 ] Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy.

[63 ] VBCRC (Victorian Breast Cancer Research Consortium) Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

[64 ] Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands.

[65 ] Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.

[66 ] Oncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona, Barcelona, Spain.

[67 ] Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute)-Catalan Institute of Oncology, Barcelona, Spain.

[68 ] Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona)-Catalan Institute of Oncology, Girona, Spain.

[69 ] Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.

[70 ] Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.

[71 ] Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

[72 ] Gynaecologic Oncology Service, Centre Hospitalier Universitaire de Québec (CHUQ), Quebec City, Quebec, Canada.

[73 ] Centre Hospitalier Universitaire de Québec (CHUQ) Research Center, Laval University, Quebec City, Quebec, Canada.

[74 ] Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV)-IRCCS, Padua, Italy.

[75 ] 1] Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal. [2] Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.

[76 ] Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

[77 ] Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

[78 ] National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.

[79 ] Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

[80 ] Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

[81 ] Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.

[82 ] Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA.

[83 ] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel.

[84 ] 1] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. [2] Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

[85 ] Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.

[86 ] 1] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

[87 ] Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, USA.

[88 ] Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.

[89 ] Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.

[90 ] Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.

[91 ] Institute of Oncology, Rivka Ziv Medical Center, Zefat, Israel.

[92 ] Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Aviv, Israel.

[93 ] Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

[94 ] Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.

[95 ] Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden.

[96 ] Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

[97 ] Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA.

[98 ] Department of Medicine and Genetics, University of California, San Francisco, San Francisco, California, USA.

[99 ] Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

[100 ] Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

[101 ] Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

[102 ] Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany.

[103 ] Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany.

[104 ] 1] Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany. [2] Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

[105 ] 1] Vesalius Research Center, VIB, Leuven, Belgium. [2] Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.

[106 ] Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium.

[107 ] Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.

[108 ] Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

[109 ] 1] Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington, USA.

[110 ] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

[111 ] Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.

[112 ] Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.

[113 ] Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.

[114 ] Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.

[115 ] 1] Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. [2] Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.

[116 ] Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany.

[117 ] Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.

[118 ] Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.

[119 ] Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus.

[120 ] 1] Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. [2] Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland.

[121 ] 1] Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. [2] Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. [3] Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. [4] Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.

[122 ] Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

[123 ] 1] Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. [2] Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

[124 ] University of Texas School of Public Health, Houston, Texas, USA.

[125 ] 1] Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany. [2] Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.

[126 ] Institut für Humangenetik Wiesbaden, Wiesbaden, Germany.

[127 ] Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan.

[128 ] Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.

[129 ] Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

[130 ] 1] Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. [2] Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

[131 ] 1] Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. [2] Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.

[132 ] Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia.

[133 ] Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.

[134 ] 1] Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia. [2] University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.

[135 ] 1] Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. [2] University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.

[136 ] Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, USA.

[137 ] Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.

[138 ] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.

[139 ] College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.

[140 ] Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

[141 ] Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

[142 ] Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.

[143 ] Department of Statistical Science, Duke University, Durham, North Carolina, USA.

[144 ] 1] Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina, USA. [2] Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.

[145 ] 1] Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA. [2] Genetics Institute, University of Florida, Gainesville, Florida, USA.

[146 ] Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.

[147 ] 1] Harvard School of Public Health, Boston, Massachusetts, USA. [2] Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

[148 ] 1] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

[149 ] Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.

[150 ] Department of Epidemiology and Biostatistics, Epidemiology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

[151 ] 1] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway. [2] Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.

[152 ] Department of Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.

[153 ] 1] Comprehensive Cancer Center The Netherlands, Utrecht, the Netherlands. [2] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands.

[154 ] 1] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands. [2] Department of Urology, Radboud University Medical Centre, Nijmegen, the Netherlands.

[155 ] 1] Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada. [2] Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.

[156 ] Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

[157 ] Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.

[158 ] Cancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

[159 ] International Hereditary Cancer Center, Department of Genetics and Pathology, Clinic of Opthalmology, Pomeranian Medical University, Szczecin, Poland.

[160 ] Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

[161 ] Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.

[162 ] Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

[163 ] Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

[164 ] Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK.

[165 ] Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK.

[166 ] Cancer Research UK Clinical Trials Unit, Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK.

[167 ] Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK.

[168 ] Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.

[169 ] Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

[170 ] Shanghai Cancer Institute, Shanghai, China.

[171 ] 1] Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. [2] Department of Gynecologic-Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada.

[172 ] Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.

[173 ] Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

[174 ] Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.

[175 ] Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida, USA.

[176 ] Department of Epidemiology, University of California-Irvine, Irvine, California, USA.

[177 ] Women's Cancer, University College London Elizabeth Garrett Anderson (EGA) Institute for Women's Health, London, UK.

[178 ] 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. [2] Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

[179 ] Department of Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.

[180 ] Department of Obstetrics, Gynecology and Oncology, 2nd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.

[181 ] Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

[182 ] 1] Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. [2] Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

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Publisher Item ID: ng.3185 Mid ID: NIHMS647338

DOI: 10.1038/ng.3185

PMC ID: 4445140

PubMed ID: 25581431

SO-VID: b1dc6248-75cf-4aec-b3f4-45f5fbf39a16

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Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

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