One of the most crucial factors affecting development in the 21st century is the increased participation of women in the economy of a country and increased entrance to managerial positions. Even though such tremendous changes have taken place, the patriarchal social set up insists on women's responsibilities towards family and children. The domestic roles of women are not shared by men despite the fact that women have shared the economic and social responsibilities of men. This causes conflict among work and family roles, which ultimately affects the physical and psychological well-being of women managers. This chapter deals with the problems and challenges faced by women managers in higher education in India and how family support and suitable coping strategies help them maintain work-family balance.