This book examines the strategies that Caribbean people used to create authoritative knowledge about the natural world, and particularly the body, during the long seventeenth century. It reveals a hitherto untold history about the transformation of early modern natural and human landscapes, one that unfolds outside existent analytical frameworks for the study of the Atlantic world. The book introduces some of the earliest and richest known records carrying the voices of people of African descent, including African themselves, to change our understanding of the dynamics and intellectual spaces in which early modern people produced transformative ideas about the natural world. Caribbean cultures of bodies and healing appeared through a localized epistemological upheaval based on the experiential and articulated by ritual specialists of African origin. These changes resulted from multiple encounters between actors coming from all over the globe that occurred in a social, spiritual, and intellectual realm that, even though ubiquitous, does not appear in existent histories of science, medicine, and the African diaspora. The intellectual leaders of the mostly black and free communities of the seventeenth century Caribbean defined not only how to interpret nature, but also the very sensorial landscapes on which reality could be experienced. They invented a powerful and lasting way of imagining, defining and dealing with the world.