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      Cancer statistics, 2024

      1 , 1 , 2
      CA: A Cancer Journal for Clinicians
      Wiley

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          Abstract

          Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population‐based cancer occurrence and outcomes using incidence data collected by central cancer registries (through 2020) and mortality data collected by the National Center for Health Statistics (through 2021). In 2024, 2,001,140 new cancer cases and 611,720 cancer deaths are projected to occur in the United States. Cancer mortality continued to decline through 2021, averting over 4 million deaths since 1991 because of reductions in smoking, earlier detection for some cancers, and improved treatment options in both the adjuvant and metastatic settings. However, these gains are threatened by increasing incidence for 6 of the top 10 cancers. Incidence rates increased during 2015–2019 by 0.6%–1% annually for breast, pancreas, and uterine corpus cancers and by 2%–3% annually for prostate, liver (female), kidney, and human papillomavirus‐associated oral cancers and for melanoma. Incidence rates also increased by 1%–2% annually for cervical (ages 30–44 years) and colorectal cancers (ages <55 years) in young adults. Colorectal cancer was the fourth‐leading cause of cancer death in both men and women younger than 50 years in the late‐1990s but is now first in men and second in women. Progress is also hampered by wide persistent cancer disparities; compared to White people, mortality rates are two‐fold higher for prostate, stomach and uterine corpus cancers in Black people and for liver, stomach, and kidney cancers in Native American people. Continued national progress will require increased investment in cancer prevention and access to equitable treatment, especially among American Indian and Alaska Native and Black individuals.

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          Sex differences in immune responses

          Males and females differ in their immunological responses to foreign and self-antigens and show distinctions in innate and adaptive immune responses. Certain immunological sex differences are present throughout life, whereas others are only apparent after puberty and before reproductive senescence, suggesting that both genes and hormones are involved. Furthermore, early environmental exposures influence the microbiome and have sex-dependent effects on immune function. Importantly, these sex-based immunological differences contribute to variations in the incidence of autoimmune diseases and malignancies, susceptibility to infectious diseases and responses to vaccines in males and females. Here, we discuss these differences and emphasize that sex is a biological variable that should be considered in immunological studies.
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            Structural racism and health inequities in the USA: evidence and interventions

            The Lancet, 389(10077), 1453-1463
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              Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial

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                Author and article information

                Contributors
                (View ORCID Profile)
                (View ORCID Profile)
                Journal
                CA: A Cancer Journal for Clinicians
                CA A Cancer J Clinicians
                Wiley
                0007-9235
                1542-4863
                January 17 2024
                Affiliations
                [1 ] Surveillance Research American Cancer Society Atlanta Georgia USA
                [2 ] Surveillance and Health Equity Science American Cancer Society Atlanta Georgia USA
                Article
                10.3322/caac.21820
                38230766
                ff2d68ca-5b21-4ab8-a2ec-f46bafbac7f6
                © 2024

                http://creativecommons.org/licenses/by-nc-nd/4.0/

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