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MicroRNA-145-5p regulates fibrotic features of recessive dystrophic epidermolysis bullosa skin fibroblasts.
A G Condorelli
1 ,
E Logli
1 ,
F Cianfarani
2 ,
M Teson
2 ,
A Diociaiuti
3 ,
M El Hachem
3 ,
G Zambruno
1 ,
D Castiglia
2 ,
T Odorisio
2
November 2019
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Abstract
Recessive dystrophic epidermolysis bullosa (RDEB) is a skin fragility disorder caused by mutations in the COL7A1 gene encoding type VII collagen, a cutaneous basement membrane component essential for epidermal-dermal adhesion. Hallmarks of the disease are unremitting blistering and chronic wounds with severe inflammation and fibrosis. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression also implicated in fibrotic processes. However, the role of miRNAs in RDEB fibrosis is almost unexplored.