The role of interleukin-1β in the immune response to contact allergens.

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Abstract

Interleukin-1β (IL-1β) is an important pro-inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL-1β and investigating the IL-1β signaling pathway, several studies have demonstrated a central role of IL-1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL-1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL-1β-targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL-1β in ACD are lacking.

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Author and article information

Journal

Journal ID (iso-abbrev): Contact Dermatitis

Title: Contact dermatitis

Publisher: Wiley

ISSN (Electronic): 1600-0536

ISSN (Print): 0105-1873

Publication date (Electronic): Oct 2021

Volume: 85

Issue: 4

Affiliations

[1 ] The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

[2 ] Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.

[3 ] Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Article

DOI: 10.1111/cod.13955

PubMed ID: 34324721

SO-VID: fd3bb035-c403-4ec2-bab6-be0adbc19f65

History

Keywords: T cells,allergic contact dermatitis,immunology,interleukin-1β

Data availability:

Keywords: T cells, allergic contact dermatitis, immunology, interleukin-1β

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