Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.

Okugawa, Yoshinaga; Toiyama, Yuji; Toden, Shusuke; Mitoma, Hiroki; Nagasaka, Takeshi; Tanaka, Koji; Inoue, Yasuhiro; Kusunoki, Masato; Boland, C. Richard; Goel, Ajay

doi:10.1136/gutjnl-2015-309359

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Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.

Author(s): Yoshinaga Okugawa, Yuji Toiyama, Shusuke Toden, Hiroki Mitoma, Takeshi Nagasaka, Koji Tanaka, Yasuhiro Inoue, Masato Kusunoki, C. Boland, Ajay Goel

Publication date: 2017

Journal: Gut

Publisher: BMJ

Keywords: COLORECTAL CANCER

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Abstract

Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clinical outcome of CRC patients. Recent evidence revealed the new role of small nucleolar RNAs (snoRNAs) in oncogenesis. Herein, we systematically evaluated dysregulation of snoRNAs in CRC and clarified their biomarker potential and biological significance in CRC.