PD-L1 is upregulated by radiochemotherapy in rectal adenocarcinoma patients and associated with a favourable prognosis.

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Abstract

The influence of neoadjuvant radiochemotherapy (RCT) on programmed death-ligand 1 (PD-L1) expression, a predictive marker for programmed cell death protein 1 (PD-1) inhibitor therapy, was studied on tumour and inflammatory cells in rectal adenocarcinoma patients along with its prognostic value.

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Journal

Journal ID (iso-abbrev): Eur. J. Cancer

Title: European journal of cancer (Oxford, England : 1990)

Publisher: Elsevier BV

ISSN (Electronic): 1879-0852

ISSN (Print): 0959-8049

Publication date (Electronic): Sep 2016

Volume: 65

Affiliations

[1 ] Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

[2 ] Department of Nephropathology, Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

[3 ] Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

[4 ] Department of Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

[5 ] Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany. Electronic address: luitpold.distel@uk-erlangen.de.

Article

Publisher Item ID: S0959-8049(16)32279-1

DOI: 10.1016/j.ejca.2016.06.015

PubMed ID: 27468145

SO-VID: fbc81fc6-954d-4d08-b9be-83b4b990b851

History

Keywords: Radiation,Radiochemotherapy,Radiotherapy,Rectal,Adenocarcinoma,Cancer,Nivolumab,PD-1,PD-L1,Pembrolizumab

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Keywords: Radiation, Radiochemotherapy, Radiotherapy, Rectal, Adenocarcinoma, Cancer, Nivolumab, PD-1, PD-L1, Pembrolizumab

PD-L1 is upregulated by radiochemotherapy in rectal adenocarcinoma patients and associated with a favourable prognosis.

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