Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial.

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Abstract

Isavuconazole is a novel triazole with broad-spectrum antifungal activity. The SECURE trial assessed efficacy and safety of isavuconazole versus voriconazole in patients with invasive mould disease.

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Author and article information

Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Feb 20 2016

Volume: 387

Issue: 10020

Affiliations

[1 ] Department of Hematology, Universitaire Ziekenhuizen Leuven, KU Leuven, Belgium.

[2 ] Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

[3 ] Department of Medicine, John Hopkins University, Baltimore, MD, USA; Department of Oncology, John Hopkins University, Baltimore, MD, USA.

[4 ] The University of Texas Health Science Center San Antonio and South Texas Veterans Health Care System, San Antonio, TX, USA.

[5 ] Department of Infectious Diseases, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

[6 ] Department of Internal Medicine, Clinical Trials Centre Cologne, ZKS Köln, Center for Integrated Oncology CIO Köln Bonn, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), German Centre for Infection Research, University of Cologne, Cologne, Germany.

[7 ] Departments of Medical Microbiology and Infectious Diseases, and Internal Medicine, the University of Manitoba, Winnipeg, Canada; Infection Control Services, CancerCare Manitoba, Winnipeg, Canada.

[8 ] The Chaim Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel Aviv University, Ramat Gan, Israel.

[9 ] Division of Infectious Diseases, John Hopkins University, Baltimore, MD, USA.

[10 ] Division of Infectious Diseases, Jules Bordet Institute, Brussels, Belgium.

[11 ] University of Alabama at Birmingham and Veterans Affairs Medical Center, Birmingham, AL, USA.

[12 ] Infectious Disease Unit, Tel Aviv Sourasky Medical Center and The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

[13 ] University of Würzburg Medical Center, Würzburg, Germany.

[14 ] Department of Oncology and Hematology, Hôpitaux Universitaires de Strasbourg and Université de Strasbourg, France.

[15 ] Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

[16 ] Klinik für Hämatologie und Onkologie, Klinikum Neuperlach, Munich, Germany.

[17 ] Division of Infectious Diseases, Department of Internal Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.

[18 ] Université Paris Descartes, Centre d'Infectiologie Necker Pasteur, Hôpital Necker Enfants Malades, IHU Imagine and Institut Pasteur, Centre National de Référence Mycoses Invasives et Antifongiques, Paris, France.

[19 ] University of Minnesota and Veterans Affairs Medical Center, Minneapolis, MN, USA.

[20 ] Infectious Diseases Unit, Rambam Health Care Campus, and the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

[21 ] Algemeen Ziekenhuis Sint-Jan Brugge-Oostende, Belgium.

[22 ] Department of Medicine, John Hopkins University, Baltimore, MD, USA.

[23 ] University of California Davis Medical Center, Davis, CA, USA.

[24 ] Astellas Pharma Global Development, Northbrook, IL, USA.

[25 ] Basilea Pharmaceutica International, Basel, Switzerland.

[26 ] Julius-Maximilians-University, Department of Internal Medicine II, Infectious Diseases, Würzburg, Germany. Electronic address: andrew.ullmann@uni-wuerzburg.de.

Article

Publisher Item ID: S0140-6736(15)01159-9

DOI: 10.1016/S0140-6736(15)01159-9

PubMed ID: 26684607

SO-VID: f81f7980-a47e-4221-9e48-0ec961ed523e

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