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      Baseline characteristics of SARS-CoV-2 vaccine non-responders in a large population-based sample

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          Abstract

          Introduction

          Studies indicate that individuals with chronic conditions and specific baseline characteristics may not mount a robust humoral antibody response to SARS-CoV-2 vaccines. In this paper, we used data from the Texas Coronavirus Antibody REsponse Survey (Texas CARES), a longitudinal state-wide seroprevalence program that has enrolled more than 90,000 participants, to evaluate the role of chronic diseases as the potential risk factors of non-response to SARS-CoV-2 vaccines in a large epidemiologic cohort.

          Methods

          A participant needed to complete an online survey and a blood draw to test for SARS-CoV-2 circulating plasma antibodies at four-time points spaced at least three months apart. Chronic disease predictors of vaccine non-response are evaluated using logistic regression with non-response as the outcome and each chronic disease + age as the predictors.

          Results

          As of April 24, 2023, 18,240 participants met the inclusion criteria; 0.58% (N = 105) of these are non-responders. Adjusting for age, our results show that participants with self-reported immunocompromised status, kidney disease, cancer, and “other” non-specified comorbidity were 15.43, 5.11, 2.59, and 3.13 times more likely to fail to mount a complete response to a vaccine, respectively. Furthermore, having two or more chronic diseases doubled the prevalence of non-response.

          Conclusion

          Consistent with smaller targeted studies, a large epidemiologic cohort bears the same conclusion and demonstrates immunocompromised, cancer, kidney disease, and the number of diseases are associated with vaccine non-response. This study suggests that those individuals, with chronic diseases with the potential to affect their immune system response, may need increased doses or repeated doses of COVID-19 vaccines to develop a protective antibody level.

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          Most cited references11

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          Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients

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            Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients

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              Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines

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                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: MethodologyRole: SupervisionRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: Formal analysisRole: MethodologyRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: MethodologyRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: Data curationRole: Formal analysisRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: Formal analysisRole: MethodologyRole: SupervisionRole: Writing – review & editing
                Role: Data curationRole: Methodology
                Role: ConceptualizationRole: Formal analysisRole: SupervisionRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: Data curationRole: Writing – review & editing
                Role: ConceptualizationRole: Writing – review & editing
                Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
                Role: ConceptualizationRole: Writing – review & editing
                Role: Data curationRole: Project administration
                Role: ConceptualizationRole: InvestigationRole: Supervision
                Role: Supervision
                Role: Supervision
                Role: SupervisionRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS One
                plos
                PLOS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                13 May 2024
                2024
                : 19
                : 5
                : e0303420
                Affiliations
                [1 ] The University of Texas Health Science Center at Houston, School of Public Health in Houston, Houston, TX, United States of America
                [2 ] The University of Texas Health Science Center at Houston, School of Public Health in Dallas, Dallas, TX, United States of America
                [3 ] Center for Pediatric Population Health, UTHealth School of Public Health, Dallas, Texas, United States of America
                [4 ] The University of Texas Health Science Center at Houston, School of Public Health in Brownville, Brownsville, TX, United States of America
                [5 ] The University of Texas Health Science Center at Houston, School of Public Health in Austin, Austin, TX, United States of America
                [6 ] University of Texas at Austin, Austin, TX, United States of America
                [7 ] University of Texas System, Austin, TX, United States of America
                [8 ] The University of Texas Health Science Center Tyler, Tyler, TX, United States of America
                [9 ] Texas Department of State Health Services, Austin, TX, United States of America
                University of Ilorin, NIGERIA
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                https://orcid.org/0000-0002-0598-3419
                https://orcid.org/0000-0002-1493-8986
                Article
                PONE-D-23-40653
                10.1371/journal.pone.0303420
                11090326
                38739625
                f811c3ac-27ff-4a94-8cfd-b0e86d60bb88
                © 2024 Yaseen et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 8 December 2023
                : 25 April 2024
                Page count
                Figures: 1, Tables: 2, Pages: 11
                Funding
                Funded by: funder-id http://dx.doi.org/10.13039/100004925, Texas Health and Human Services Commission;
                Award ID: #HHS000866600001
                Award Recipient :
                Project funded by Texas Department of State Health Services (Grant #HHS000866600001).
                Categories
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                Custom metadata
                Data cannot be shared publicly because the data contain potentially identifying or sensitive participants’ information. Data are available from the Texas Department of State Health Services Institutional Review Board (contact via institutionalreviewboard@ 123456dshs.texas.gov ) for researchers who meet the criteria for access to confidential data. De-identified datasets can be made available upon reasonable request and within a reasonable time in accordance with the general spirit of colleagueship within the scientific community and with policies adopted by UTHealth Houston and the Texas Department of State Health Services. Please submit data requests to institutionalreviewboard@ 123456dshs.texas.gov . Texas CARES investigators are committed to data sharing. Granular results and user-specified data summaries are currently publicly available on the Texas CARES portal ( https://sph.uth.edu/projects/texascares/dashboard). Upon project completion, de-identified secondary data and detailed documentation will be made publicly available through the same portal as open-access data sources after de-identification and collapsing cells to protect individuals representing rare events or conditions.
                COVID-19

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