Precision epidemiology for infectious disease control

Ladner, Jason T.; Grubaugh, Nathan D; Pybus, Oliver G.; Andersen, Kristian G.

doi:10.1038/s41591-019-0345-2

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Precision epidemiology for infectious disease control

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Author(s): Jason T. Ladner ¹ , Nathan D. Grubaugh ² , Oliver G. Pybus ³ , Kristian G. Andersen ⁴ ^, ⁵ ^,

Publication date (Electronic): 6 February 2019

Journal: Nature Medicine

Publisher: Nature Publishing Group US

Keywords: Epidemiology, Genetics research, Evolution, Immunology, Microbiology

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Abstract

Advances in genomics and computing are transforming the capacity for the characterization of biological systems, and researchers are now poised for a precision-focused transformation in the way they prepare for, and respond to, infectious diseases. This includes the use of genome-based approaches to inform molecular diagnosis and individual-level treatment regimens. In addition, advances in the speed and granularity of pathogen genome generation have improved the capability to track and understand pathogen transmission, leading to potential improvements in the design and implementation of population-level public health interventions. In this Perspective, we outline several trends that are driving the development of precision epidemiology of infectious disease and their implications for scientists’ ability to respond to outbreaks.

Abstract

The emerging field of precision epidemiology allows the personalized diagnosis, tracking and treatment of infectious diseases.

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Author and article information

Contributors

Kristian G. Andersen:

ORCID: http://orcid.org/0000-0001-6431-5982

andersen@scripps.edu

Journal

Journal ID (nlm-ta): Nat Med

Journal ID (iso-abbrev): Nat. Med

Title: Nature Medicine

Publisher: Nature Publishing Group US (New York )

ISSN (Print): 1078-8956

ISSN (Electronic): 1546-170X

Publication date (Electronic): 6 February 2019

Publication date (Print): 2019

Volume: 25

Issue: 2

Pages: 206-211

Affiliations

[1 ]ISNI 0000 0004 1936 8040, GRID grid.261120.6, Pathogen and Microbiome Institute, , Northern Arizona University, ; Flagstaff, AZ USA

[2 ]ISNI 0000000419368710, GRID grid.47100.32, Department of Epidemiology of Microbial Diseases, , Yale School of Public Health, ; New Haven, CT USA

[3 ]ISNI 0000 0004 1936 8948, GRID grid.4991.5, Department of Zoology, , University of Oxford, ; Oxford, UK

[4 ]ISNI 0000000122199231, GRID grid.214007.0, Department of Immunology and Microbiology, , The Scripps Research Institute, ; La Jolla, CA USA

[5 ]Scripps Research Translational Institute, La Jolla, CA USA

Author information

Kristian G. Andersen http://orcid.org/0000-0001-6431-5982

Article

Publisher ID: 345

DOI: 10.1038/s41591-019-0345-2

PMC ID: 7095960

PubMed ID: 30728537

SO-VID: f7504e6b-35bc-4a5f-a16a-f51047d2e1c9

License:

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.