For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
5
views
59
references
 Top references
cited by
73
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      295
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Key Points

          Children with AL given haplo-HSCT after αβ T- and B-cell depletion are exposed to a low risk of acute and chronic GVHD and NRM. The leukemia-free, GVHD-free survival of patients given this type of allograft is comparable to that of HLA-matched donor HSCT recipients.

          Related collections

          Most cited references59

          • Record: found
          • Abstract: not found
          • Article: not found

          Nonparametric Estimation from Incomplete Observations

          E. Kaplan, Paul Meier (1958)
          Article 0 comments Cited 1123 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk

            Robert J Gray (1988)
            Article 0 comments Cited 528 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants.

              Loredana Ruggeri, Marusca Capanni, Elena Urbani … (2002)
              T cells that accompany allogeneic hematopoietic grafts for treating leukemia enhance engraftment and mediate the graft-versus-leukemia effect. Unfortunately, alloreactive T cells also cause graft-versus-host disease (GVHD). T cell depletion prevents GVHD but increases the risk of graft rejection and leukemic relapse. In human transplants, we show that donor-versus-recipient natural killer (NK)-cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD. In mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GVHD. NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation.
              Article 0 comments Cited 321 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Title: Blood
                Publisher: American Society of Hematology
                ISSN (Print): 0006-4971
                ISSN (Electronic): 1528-0020
                Publication date Created: August 03 2017
                Publication date (Print): August 03 2017
                Volume: 130
                Issue: 5
                Pages: 677-685
                Affiliations
                [1 ]Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Bambino Gesù, Rome, Italy;
                [2 ]Department of Pediatric Science, Università di Pavia, Pavia, Italy;
                [3 ]Dipartimento di Ricerca e Diagnostica, UOC Immunologia Clinica e Sperimentale, Istituto di Ricovero e Cura a Carattere Scientifico Giannina Gaslini, Genoa, Italy;
                [4 ]UOC Immunologia, Ospedale Policlinico San Martino, Genoa, Italy;
                [5 ]Department of Pediatrics, Sant’Orsola Hospital, University of Bologna, Bologna, Italy;
                [6 ]Department of Radiotherapy, Policlinico Umberto I, Rome, Italy;
                [7 ]Department of Pediatric Hematology and Oncology, Children's University Hospital, University of Tuebingen, Tuebingen, Germany;
                [8 ]Dipartimento di Medicina Sperimentale and Centro di Eccellenza per la Ricerca Biomedica, Università di Genova, Genoa, Italy; and
                [9 ]Immunology Research Area, IRCCS Ospedale Bambino Gesù, Rome, Italy
                Article
                DOI: 10.1182/blood-2017-04-779769
                PubMed ID: 28588018
                SO-VID: ee50874c-55af-4fa4-b9b0-d030b9cd0581
                Copyright © © 2017
                History

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content295

                See all similar

                Cited by124

                See all cited by

                Most referenced authors885

                See all reference authors