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      Feasibility of an eHealth Service to Support Collaborative Depression Care: Results of a Pilot Study

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          Abstract

          Background

          Treatments and organizational changes supported by eHealth are beginning to play an important role in improving disease treatment outcome and providing cost-efficient care management. “Improvehealth.eu” is a novel eHealth service to support the treatment of patients with depressive disorder. It offers active patient engagement and collaborative care management by combining Web- and mobile-based information and communication technology systems and access to care managers.

          Objectives

          Our objective was to assess the feasibility of a novel eHealth service.

          Methods

          The intervention—the “Improvehealth.eu” service—was explored in the course of a pilot study comparing two groups of patients receiving treatment as usual and treatment as usual with eHealth intervention. We compared patients’ medication adherence and outcome measures between both groups and additionally explored usage and overall perceptions of the intervention in intervention group.

          Results

          The intervention was successfully implemented in a pilot with 46 patients, of whom 40 were female. Of the 46 patients, 25 received treatment as usual, and 21 received the intervention in addition to treatment as usual. A total of 55% (12/25) of patients in the former group and 45% (10/21) in the latter group finished the 6-month pilot. Available case analysis indicated an improvement of adherence in the intervention group (odds ratio [OR] = 10.0, P = .03). Intention-to-treat analysis indicated an improvement of outcome in the intervention group (ORs ranging from 0.35 to 18; P values ranging from .003 to .20), but confidence intervals were large due to small sample sizes. Average duration of use of the intervention was 107 days. The intervention was well received by 81% (17/21) of patients who reported feeling actively engaged, in control of their disease, and that they had access to a high level of information. In all, 33% (7/21) of the patients also described drawbacks of the intervention, mostly related to usability issues.

          Conclusions

          The results of this pilot study indicate that the intervention was well accepted and helped the patients in the course of treatment. The results also suggest the potential of the intervention to improve both medication adherence and outcome measures of treatment, including reduction of depression severity and patients becoming “healthy.”

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          Most cited references33

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          Collaborative care for depression: a cumulative meta-analysis and review of longer-term outcomes.

          Depression is common in primary care but is suboptimally managed. Collaborative care, that is, structured care involving a greater role of nonmedical specialists to augment primary care, has emerged as a potentially effective candidate intervention to improve quality of primary care and patient outcomes. To quantify the short-term and longer-term effectiveness of collaborative care compared with standard care and to understand mechanisms of action by exploring between-study heterogeneity, we conducted a systematic review of randomized controlled trials that compared collaborative care with usual primary care in patients with depression. We searched MEDLINE (from the beginning of 1966), EMBASE (from the beginning of 1980), CINAHL (from the beginning of 1980), PsycINFO (from the beginning of 1980), the Cochrane Library (from the beginning of 1966), and DARE (Database of Abstracts of Reviews of Effectiveness) (from the beginning of 1985) databases from study inception to February 6, 2006. We found 37 randomized studies including 12 355 patients with depression receiving primary care. Random effects meta-analysis showed that depression outcomes were improved at 6 months (standardized mean difference, 0.25; 95% confidence interval, 0.18-0.32), and evidence of longer-term benefit was found for up to 5 years (standardized mean difference, 0.15; 95% confidence interval, 0.001-0.31). When exploring determinants of effectiveness, effect size was directly related to medication compliance and to the professional background and method of supervision of case managers. The addition of brief psychotherapy did not substantially improve outcome, nor did increased numbers of sessions. Cumulative meta-analysis showed that sufficient evidence had emerged by 2000 to demonstrate the statistically significant benefit of collaborative care. Collaborative care is more effective than standard care in improving depression outcomes in the short and longer terms. Future research needs to address the implementation of collaborative care, particularly in settings other than the United States.
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            Interventions to enhance medication adherence in chronic medical conditions: a systematic review.

            Approximately 20% to 50% of patients are not adherent to medical therapy. This review was performed to summarize, categorize, and estimate the effect size (ES) of interventions to improve medication adherence in chronic medical conditions. Randomized controlled trials published from January 1967 to September 2004 were eligible if they described 1 or more unconfounded interventions intended to enhance adherence with self-administered medications in the treatment of chronic medical conditions. Trials that reported at least 1 measure of medication adherence and 1 clinical outcome, with at least 80% follow-up during 6 months, were included. Study characteristics and results for adherence and clinical outcomes were extracted. In addition, ES was calculated for each outcome. Among 37 eligible trials (including 12 informational, 10 behavioral, and 15 combined informational, behavioral, and/or social investigations), 20 studies reported a significant improvement in at least 1 adherence measure. Adherence increased most consistently with behavioral interventions that reduced dosing demands (3 of 3 studies, large ES [0.89-1.20]) and those involving monitoring and feedback (3 of 4 studies, small to large ES [0.27-0.81]). Adherence also improved in 6 multisession informational trials (small to large ES [0.35-1.13]) and 8 combined interventions (small to large ES [absolute value, 0.43-1.20]). Eleven studies (4 informational, 3 behavioral, and 4 combined) demonstrated improvement in at least 1 clinical outcome, but effects were variable (very small to large ES [0.17-3.41]) and not consistently related to changes in adherence. Several types of interventions are effective in improving medication adherence in chronic medical conditions, but few significantly affected clinical outcomes.
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              Adherence to Long-Term Therapies: Evidence for Action

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                Author and article information

                Contributors
                Journal
                J Med Internet Res
                JMIR
                Journal of Medical Internet Research
                Gunther Eysenbach (Centre for Global eHealth Innovation, Toronto, Canada )
                1438-8871
                Oct-Dec 2010
                19 December 2010
                : 12
                : 5
                : e63
                Affiliations
                [9] 9simpleCentre for Global eHealth Innovation simpleUniversity Health Network Toronto, ONCanada
                [8] 8simpleDepartment of Health Policy, Management and Evaluation simpleUniversity of Toronto Toronto, ONCanada
                [7] 7simpleUniversity Psychiatric Hospital Ljubljana LjubljanaSlovenia
                [6] 6simplePrimary Health Care Centre Brezice BreziceSlovenia
                [5] 5simpleAmbulanta Kosir d.o.o. Skofja LokaSlovenia
                [4] 4simplePsihiatricna Ambulanta Vrhnika VrhnikaSlovenia
                [3] 3simplePrimary Health Care Centre Cerknica CerknicaSlovenia
                [2] 2simpleHealth Care Centre Celjenje KoperSlovenia
                [1] 1simplePrimorska Institute of Nature Science and Technology simpleUniversity of Primorska KoperSlovenia
                Article
                v12i5e63
                10.2196/jmir.1510
                3057312
                21172765
                ee3fd9ff-807e-43b6-9c58-84383eb48e86
                ©Matic Meglic, Mirjana Furlan, Marja Kuzmanic, Dejan Kozel, Dusan Baraga, Irma Kuhar, Branko Kosir, Rade Iljaz, Brigita Novak-Sarotar, Mojca Zvezdana Dernovsek, Andrej Marusic, Gunther Eysenbach, Andrej Brodnik. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 19.12.2010  

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.

                History
                : 02 February 2010
                : 26 February 2010
                : 08 June 2010
                : 09 June 2010
                Categories
                Original Paper

                Medicine
                depression,patient care management,information systems,internet,treatment outcome,medication adherence,pilot study,feasibility study,collaborative care

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