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      Green and Scalable Preparation of Colloidal Suspension of Lignin Nanoparticles and Its Application in Eco-friendly Sunscreen Formulations

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          Abstract

          Lignin nanoparticles (LNPs) are applied in several industrial applications. The nanoprecipitation of LNPs is fast and inexpensive but currently still limited to the use of hazardous organic solvents, making it difficult to apply them on a large scale. Here, we report a scalable nanoprecipitation procedure for the preparation of colloidal lignin nanoparticles (cLNPs) by the use of the green solvents dimethylisosorbide and isopropylidene glycerol. Irrespective of the experimental conditions, cLNPs showed higher UV absorbing properties and radical scavenging activity than parent LNPs and raw lignin. cLNPs were successively used in the preparation of eco-friendly sunscreen formulations (SPF 15, 30, and 50+, as evaluated by the COLIPA assay), which showed high UV-shielding activity even in the absence of synthetic boosters (microplastics) and physical filters (TiO 2 and ZnO). Biological assays on human HaCaT keratinocytes and human skin equivalents demonstrated the absence of cytotoxicity and genotoxicity, associated with an optimal protection of the skin from UV-A damage.

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          Lignin valorization: improving lignin processing in the biorefinery.

          Research and development activities directed toward commercial production of cellulosic ethanol have created the opportunity to dramatically increase the transformation of lignin to value-added products. Here, we highlight recent advances in this lignin valorization effort. Discovery of genetic variants in native populations of bioenergy crops and direct manipulation of biosynthesis pathways have produced lignin feedstocks with favorable properties for recovery and downstream conversion. Advances in analytical chemistry and computational modeling detail the structure of the modified lignin and direct bioengineering strategies for future targeted properties. Refinement of biomass pretreatment technologies has further facilitated lignin recovery, and this coupled with genetic engineering will enable new uses for this biopolymer, including low-cost carbon fibers, engineered plastics and thermoplastic elastomers, polymeric foams, fungible fuels, and commodity chemicals.
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            Lignin as renewable raw material.

            Lignin is by far the most abundant substance based on aromatic moieties in nature, and the largest contributor to soil organic matter. Millions of tonnes of several lignin preparations are produced by the paper industry every year, and a minimal amount of lignin is isolated by direct extraction of lignin from plants. Lignin is used either directly or chemically modified, as a binder, dispersant agent for pesticides, emulsifier, heavy metal sequestrant, or component for composites and copolymers. For value-added applications of lignin to be improved, medium- and long-term conversion technologies must be developed, especially for the preparation of low-molecular-weight compounds as an alternative to the petrochemical industry.
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              Properties and chemical modifications of lignin: Towards lignin-based nanomaterials for biomedical applications

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                Author and article information

                Journal
                ACS Omega
                ACS Omega
                ao
                acsodf
                ACS Omega
                American Chemical Society
                2470-1343
                09 August 2021
                24 August 2021
                : 6
                : 33
                : 21444-21456
                Affiliations
                []Department of Biological and Ecological Sciences, University of Tuscia , Via S. Camillo de Lellis, 01100 Viterbo, Italy
                []Department of Physical and Chemical Sciences, University of Aquila , Via Vetoio I, Coppito, 67100 L’Aquila, Italy
                [§ ]IDI Farmaceutici , Via dei castelli Romani 73/75, Pomezia 00071, Rome, Italy
                Author notes
                Author information
                https://orcid.org/0000-0002-4420-9063
                Article
                10.1021/acsomega.1c02268
                8387983
                34471747
                ec461f7b-85a7-4bd8-aff3-8197ff3f8ecb
                © 2021 The Authors. Published by American Chemical Society

                Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works ( https://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 30 April 2021
                : 16 July 2021
                Funding
                Funded by: European Commission, doi 10.13039/501100000780;
                Award ID: 2018/n.86369
                Funded by: FISR project LIOO, doi NA;
                Award ID: NA
                Categories
                Article
                Custom metadata
                ao1c02268
                ao1c02268

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