Definition and Antagonism of Histamine H2-receptors

BLACK, J W; Parsons, E M; Ganellin, C R; DURANT, C. J.; DUNCAN, W. A. M.

doi:10.1038/236385a0

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Definition and Antagonism of Histamine H2-receptors

Author(s): J. W. BLACK , W. A. M. DUNCAN , C. J. DURANT , C. R. GANELLIN , E. M. PARSONS

Publication date (Print): April 1972

Journal: Nature

Publisher: Springer Nature

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Some quantitative uses of drug antagonists.

O ARUNLAKSHANA, H O Schild (1959)

Various applications of pA(x) measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pA(x) measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine-atropine, histamine-atropine and acetylcholine-cinchonidine. A new measure, pA(h), is introduced to express the activity of unsurmountable antagonists.

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Gastric Secretion in Dogs Treated with Histamine Antagonist, Thymoxyethyldiethylamine

E R Loew, O. Chickering (1941)

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HISTAMINE AS A NORMAL STIMULANT OF GASTRIC SECRETION

Randall C. Macintosh, RANDALL C. MacINTOSH (1938)

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Author and article information

Journal

Title: Nature

Abbreviated Title: Nature

Publisher: Springer Nature

ISSN (Print): 0028-0836

ISSN (Electronic): 1476-4687

Publication date Created: April 1972

Publication date (Print): April 1972

Volume: 236

Issue: 5347

Pages: 385-390

Article

DOI: 10.1038/236385a0

PubMed ID: 4401751

SO-VID: ebbea588-2a74-4ba8-8607-569b3af9ab42

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