Correction: DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

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The first author’s name is spelled incorrectly. The correct name is: Yuelong Yan. The correct citation is: Yan Y, Zhang C, Hao J, Wang X-L, Ming J, Mi L, et al. (2019) DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program. PLoS Biol 17(6): e3000324. https://doi.org/10.1371/journal.pbio.3000324

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DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

Yao-Long Yan, Chao Zhang, Jing HAO … (2019)

The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals remains poorly understood. The 2-cell (2C)-like cells spontaneously emerging from cultures of mouse embryonic stem cells (ESCs) share some key transcriptional and epigenetic programs with 2C-stage embryos. By studying the transition of ESCs into 2C-like cells, we identified developmental pluripotency associated 2 and 4 (Dppa2/4) as important regulators controlling zygotic transcriptional program through directly up-regulating the expression of double homeobox (Dux). In addition, we found that DPPA2 protein is sumoylated and its activity is negatively regulated by small ubiquitin-like modifier (Sumo) E3 ligase protein inhibitor of activated STAT 4 (PIAS4). PIAS4 is down-regulated during ZGA process and during transitioning of ESCs into 2C-like cells. Depleting Pias4 or overexpressing Dppa2/4 is sufficient to activate 2C-like transcriptional program, whereas depleting Dppa2/4 or forced expression of Pias4 or Sumo2–Dppa2 inhibits 2C-like transcriptional program. Furthermore, ectopic expression of Pias4 or Sumo2–Dppa2 impairs early mouse embryo development. In summary, our study identifies key molecular rivals consisting of transcription factors and a Sumo2 E3 ligase that regulate zygotic transcriptional program upstream of Dux.

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Journal ID (nlm-ta): PLoS Biol

Journal ID (iso-abbrev): PLoS Biol

Journal ID (publisher-id): plos

Title: PLOS Biology

Publisher: Public Library of Science (San Francisco, CA USA )

ISSN (Print): 1544-9173

ISSN (Electronic): 1545-7885

Publication date (Electronic): 9 November 2023

Publication date Collection: November 2023

Publication date PMC-release: 9 November 2023

Volume: 21

Issue: 11

Electronic Location Identifier: e3002379

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Publisher ID: PBIOLOGY-D-23-02695

DOI: 10.1371/journal.pbio.3002379

PMC ID: 10635676

SO-VID: eb337543-f43c-45af-b9e8-7ad477ca530c

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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Correction: DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

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DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

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