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      Conducting Patient-Pathway Analysis to Inform Programming of Tuberculosis Services: Methods

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          Abstract

          Patient-centered care is a central pillar of the World Health Organization’s End TB Strategy. Understanding where patients access health services is a first step to planning for the placement of services to meet patient needs and preferences. The patient-pathway analysis (PPA) methodology detailed in this article was developed to better understand the alignment between patient care seeking and tuberculosis service availability. A PPA describes the steps that people with tuberculosis take from the initial care visit to cure. The results of a PPA reveal programmatic gaps in care seeking, diagnosis, treatment initiation, and continuity of care. They can be used as inputs to an evidence-based process of identifying and developing interventions to address the gaps in patient care. This paper summarizes the steps to conduct a PPA and serves as the basis for understanding country case studies that profile the use of PPA.

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          Size and Usage Patterns of Private TB Drug Markets in the High Burden Countries

          Background Tuberculosis (TB) control is considered primarily a public health concern, and private sector TB treatment has attracted less attention. Thus, the size and characteristics of private sector TB drug sales remain largely unknown. Methodology/Principal Findings We used IMS Health data to analyze private TB drug consumption in 10 high burden countries (HBCs), after first mapping how well IMS data coverage overlapped with private markets. We defined private markets as any channels not used or influenced by national TB programs. Private markets in four countries – Pakistan, the Philippines, Indonesia and India – had the largest relative sales volumes; annually, they sold enough first line TB drugs to provide 65–117% of the respective countries' estimated annual incident cases with a standard 6–8 month regimen. First line drug volumes in five countries were predominantly fixed dose combinations (FDCs), but predominantly loose drugs in the other five. Across 10 countries, these drugs were available in 37 (loose drug) plus 74 (FDCs) distinct strengths. There were 54 distinct, significant first line manufacturers (range 2–11 per country), and most companies sold TB drugs in only a single study country. FDC markets were, however, more concentrated, with 4 companies capturing 69% of FDC volume across the ten countries. Among second line drugs, fluoroquinolones were widely available, with significant volumes used for TB in India, Pakistan and Indonesia. However, certain WHO-recommended drugs were not available and in general there were insufficient drug volumes to cover the majority of the expected burden of multidrug-resistant TB (MDR-TB). Conclusions/Significance Private TB drug markets in several HBCs are substantial, stable, and complicated. This calls for appropriate policy and market responses, including expansion of Public-Private Mix (PPM) programs, greater reach, flexibility and appeal of public programs, regulatory and quality enforcement, and expansion of public MDR-TB treatment programs.
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            How do patients access the private sector in Chennai, India? An evaluation of delays in tuberculosis diagnosis.

            The diagnosis and treatment of tuberculosis (TB) in India are characterized by heavy private-sector involvement. Delays in treatment remain poorly characterized among patients seeking care in the Indian private sector.
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              Increasing access to tuberculosis services in Ethiopia: findings from patient-pathway analysis

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                Author and article information

                Journal
                J Infect Dis
                J. Infect. Dis
                jid
                The Journal of Infectious Diseases
                Oxford University Press (US )
                0022-1899
                1537-6613
                01 October 2017
                06 November 2017
                06 November 2017
                : 216
                : Suppl 7 , Using Patient Pathways to Accelerate the Drive to Ending Tuberculosis
                : S679-S685
                Affiliations
                [1 ] Macalester College , St. Paul, Minnesota
                [2 ] Bill and Melinda Gates Foundation and
                [3 ] Linksbridge , Seattle, Washington
                Author notes
                Correspondence: C. L. Hanson, PhD, Gates Foundation, 440 5th Ave N, Seattle, WA 98109 ( Christy.Hanson@ 123456gatesfoundation.org ).
                Article
                jix387
                10.1093/infdis/jix387
                5853893
                29117350
                e4fca999-b754-4f3a-8ab3-240f584fcc0b
                © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Page count
                Pages: 7
                Categories
                Supplement Articles

                Infectious disease & Microbiology
                tuberculosis,patient pathway analysis,care seeking,diagnosis,private sector

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