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Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat
Sinan Canpolat ,
Suleyman Sandal ,
Bayram Yilmaz ,
Abdullah Yasar ,
Selim Kutlu ,
Giyasettin Baydas ,
Haluk Kelestimur
September 2001
September 2001
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Abstract
The effects of pinealectomy and exogenous melatonin (N-acetyl-5-methoxytryptamine)
on serum leptin levels were investigated in rats. Exogenous administration of melatonin
to intact rats resulted in significant decreases in serum leptin levels (P < 0.05)
compared to those of the intact control group. Serum leptin levels were significantly
elevated in the pinealectomised rats in comparison to the sham-pinealectomised animals
(P < 0.001) and were significantly suppressed by exogenous administration of melatonin
compared to those of non-treated pinealectomised rats (P < 0.001). Hormone concentrations
in the melatonin-treated pinealectomised group were found to be similar to those seen
in the sham-pinealectomised group. These results suggest that pineal gland has an
effect on leptin release.