The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population

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Abstract

Background

Klotho is an important factor involving aging process. Recently, polycyclic aromatic hydrocarbons (PAHs) exposure was reported to have adverse impact on DNA methylation associated with aging. The aim of the current study was to determine the relationship between serum klotho and PAHs exposure in an adult population.

Methods

A total of 2597 participants obtained from NHANES 2015–2016 were included in this cross-sectional study. Serum klotho levels were analyzed by enzyme-linked immunosorbent assay (ELISA). PAHs exposure was estimated by urinary sample using liquid chromatography-tandem mass spectrometry. The relationship between serum klotho and exposure to PAHS was analyzed by a multivariable linear regression model.

Results

2-napthol and 3-fluorene were significantly associated with decreased klotho. After fully adjusting pertinent variables, PAH exposure was significantly associated with decreased klotho, particularly in men.

Conclusion

In the present study we highlighted the significant association between PAHs exposure and serum klotho levels. The importance of environmental effect on aging process and age-related disorders should be paid more attention and clinical intervention is necessary.

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Most cited references 52

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Functions of DNA methylation: islands, start sites, gene bodies and beyond.

Peter A. Jones (2012)

DNA methylation is frequently described as a 'silencing' epigenetic mark, and indeed this function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved genome-scale mapping of methylation, we can evaluate DNA methylation in different genomic contexts: transcriptional start sites with or without CpG islands, in gene bodies, at regulatory elements and at repeat sequences. The emerging picture is that the function of DNA methylation seems to vary with context, and the relationship between DNA methylation and transcription is more nuanced than we realized at first. Improving our understanding of the functions of DNA methylation is necessary for interpreting changes in this mark that are observed in diseases such as cancer.

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A review on polycyclic aromatic hydrocarbons: Source, environmental impact, effect on human health and remediation

Hussein I. Abdel-Shafy, Mona S.M. Mansour (2016)

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Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.

Ming Hu, Kazuhiro Shiizaki, Makoto Kuro-O … (2013)

The metabolically active and perpetually remodeling calcium phosphate-based endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and phosphate homeostasis that involves multiple organs in terms of mineral flux and endocrine cross talk. The fibroblast growth factor (FGF)-Klotho endocrine networks epitomize the complexity of systems biology, and specifically, the FGF23-αKlotho axis highlights the concept of the skeleton holding the master switch of homeostasis rather than a passive target organ as hitherto conceived. Other than serving as a coreceptor for FGF23, αKlotho circulates as an endocrine substance with a multitude of effects. This review covers recent data on the physiological regulation and function of the complex FGF23-αKlotho network. Chronic kidney disease is a common pathophysiological state in which FGF23-αKlotho, a multiorgan endocrine network, is deranged in a self-amplifying vortex resulting in organ dysfunction of the utmost severity that contributes to its morbidity and mortality.

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Author and article information

Contributors

Wei-Liang Chen: weiliang0508@gmail.com

Journal

Journal ID (nlm-ta): BMC Geriatr

Journal ID (iso-abbrev): BMC Geriatr

Title: BMC Geriatrics

Publisher: BioMed Central (London )

ISSN (Electronic): 1471-2318

Publication date (Electronic): 14 March 2022

Publication date PMC-release: 14 March 2022

Publication date Collection: 2022

Volume: 22

Electronic Location Identifier: 198

Affiliations

[1 ]GRID grid.260565.2, ISNI 0000 0004 0634 0356, Department of Pathology, Tri-Service General Hospital, and School of Medicine, , National Defense Medical Center, ; Taipei, Taiwan, Republic of China

[2 ]GRID grid.260565.2, ISNI 0000 0004 0634 0356, Department of Pathology, Tri-Service General Hospital Songshan Branch, and School of Medicine, , National Defense Medical Center, ; Taipei, Taiwan, Republic of China

[3 ]GRID grid.260565.2, ISNI 0000 0004 0634 0356, Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, , National Defense Medical Center, ; Taipei, Taiwan, Republic of China

[4 ]GRID grid.260565.2, ISNI 0000 0004 0634 0356, Department of Biochemistry, , National Defense Medical Center, ; Taipei, Taiwan, Republic of China

Article

Publisher ID: 2924

DOI: 10.1186/s12877-022-02924-9

PMC ID: 8919518

PubMed ID: 35287592

SO-VID: e2234235-3af1-4dd3-96b3-ed14bbc0f1c5

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 22 October 2021

Date accepted : 9 March 2022

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ScienceOpen disciplines: Geriatric medicine

Keywords: polycyclic aromatic hydrocarbons,klotho,adult

Data availability:

ScienceOpen disciplines: Geriatric medicine

Keywords: polycyclic aromatic hydrocarbons, klotho, adult

The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population

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Most cited references 52

Functions of DNA methylation: islands, start sites, gene bodies and beyond.

A review on polycyclic aromatic hydrocarbons: Source, environmental impact, effect on human health and remediation

Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.

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