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      Intention to vaccinate against COVID-19 in Australia

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          Abstract

          As the COVID-19 pandemic continues, we eagerly await the arrival of safe and effective COVID-19 vaccines. However, the success of any vaccination programme depends on high vaccine acceptance and uptake. Previously, Rachael Dodd and colleagues 1 reported that 4·9% of adults in Australia would refuse a vaccine, which is low compared with estimates in the USA (20%) 2 and France (27%). 3 The Australian data were collected in April, 2020, 4 weeks after lockdown measures commenced, which was at a time when community transmission was perceived to be high. As part of the Royal Children's Hospital National Child Health Poll, 4 we did an intention-to-vaccinate analysis in a nationally representative sample of Australian parents (n=2018) during June 15–23, 2020, and collected data via an online survey. At this time, restrictions had been eased throughout Australia and there was minimal community transmission. Compared with the earlier Australian estimates, 1 the weighted proportion of people in our study indicating that they were unsure or unwilling to accept a COVID-19 vaccine had increased by 10·0% (14·2% in April 1 to a weighted proportion of 24·2% in June [95% CI 7·9–12·1]; p<0·0001). Among parents who were unsure (320 [16·7%]) or unwilling (138 [7·6%]) to accept a COVID-19 vaccine, 379 (82·8%) were concerned about vaccine efficacy and safety, and 123 (26·9%) believed that a COVID-19 vaccine was unnecessary. Similar to the data from France, 3 our findings show that women, who play a crucial role in childhood vaccination, and people with a lower socioeconomic status, might be less likely to accept a COVID-19 vaccine than men and people with a higher socioeconomic status (appendix p 1). Furthermore, similar to the earlier Australian estimates, 1 vaccine hesitancy or refusal was associated with being younger than 60 years of age, having a lower level of education, and having inadequate knowledge about the recommended actions required by a person if they were to develop symptoms consistent with COVID-19 infection. We did not find an association between cultural background (ie, country of birth or language spoken at home) and vaccine acceptance. The observed decrease in the proportion of people who would accept a COVID-19 vaccine over 2 months in Australia could be associated with the perception of a reduced risk of infection and disease severity of COVID-19. Population attitudes towards COVID-19 vaccine uptake will fluctuate with the waves of the pandemic, necessitating regular tracking of vaccine confidence among different population groups to ensure public health campaigns remain responsive to community vaccine sentiments. Given the potential impact of vaccine hesitancy on the required population herd immunity threshold, we need to understand the attitudinal and behavioural drivers in order to inform community-led communication strategies to build trust and optimise COVID-19 vaccine uptake.

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          A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicisation

          Just a few weeks ago, more than half of the world's population was on lockdown to limit the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Scientists are racing against time to provide a proven treatment. Beyond the current outbreak, in the longer term, the development of vaccines against SARS-CoV-2 and their global access are a priority to end the pandemic. 1 However, the success of this strategy relies on people's acceptability of immunisation: what if people do not want the shot? This question is not rhetorical; many experts have warned against a worldwide decline in public trust in immunisation and the rise of vaccine hesitancy during the past decade, especially in whole Europe and in France.2, 3 Early results from a survey done in late March in France suggests that this distrust is likely to become an issue when the vaccine will be made available. We did an online survey in a representative sample of the French population aged 18 years and older 10 days after the nationwide lockdown was introduced (March 27–29). We found that 26% of respondents stated that, if a vaccine against SARS-CoV-2 becomes available, they would not use it. It might come as a surprise given the situation a few weeks ago: the whole population was confined as the outbreak had not yet reached its peak, and media were flooded with daily death tolls and the saturation of intensive care wards. The social profile of reluctant responders is even more worrying: this attitude was more prevalent among low-income people (37%), who are generally more exposed to infectious diseases, 4 among young women (aged 18–35 years; 36%), who play a crucial role regarding childhood vaccination, 5 and among people aged older than 75 years (22%), who are probably at an increased risk for severe illness from COVID-19. Our data also suggest that the political views of respondents play an important part in their attitude. Participants' acceptation of a vaccine against SARS-CoV-2 strongly depended on their vote at the first round of the 2017 presidential election (figure ): those who had voted for a far left or far right candidate were much more likely to state that they would refuse the vaccine, as well as those who abtained from voting. Figure The French public's intention to refuse vaccination against COVID-19 according to their vote at the first round of the 2017 presidential election, March 27–29, COCONEL Survey (n=1012) These early results are not entirely surprising. When this dimension has been studied, researchers have often found a connection between political beliefs and attitudes to vaccines. 6 They highlight a crucial issue for public health interventions: how can we assure the public that recommendations reflect the state of scientific knowledge rather than political interests? This problem is exacerbated in times of crisis, during which there is considerable scientific uncertainty, available measures have a limited effect, and politicians—rather than experts—are the public face of crisis management. This is one of the lessons that can be drawn from the H1N1 influenza pandemic of 2009 in France. As the pandemic unfolded, the apparent national unity of the early phase broke apart. Criticism of the government's strategy was voiced by prominent members of nearly all of the opposition parties. 7 A public debate around the safety of the vaccine arose, with prominent politicians and activists claiming that it had been produced too hastily and not been tested enough. This was crucial in the failure of the vaccination campaign (only 8% of the population was vaccinated). 8 It also ushered in an era of perpetual debate over vaccination in France. 9 One of the crucial mistakes made at the time by French authorities was to refuse to communicate early on the measures taken to ensure the safety of the vaccine for fear that the mere evocation of risk might provoke irrational reactions. 10 This approach let critics set the agenda on this issue, condemning public authorities to a defensive position. Public authorities are setting up fast-track approval processes for a putative vaccine against SARS-CoV-2. 9 It is crucial to communicate early and transparently on these processes to avoid vaccines becoming part of political debates.
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            Willingness to vaccinate against COVID-19 in Australia

            More than half of the world's population faces long-term restrictions as the new normal to prevent the spread of COVID-19. If a vaccine becomes available, it might be possible to develop herd immunity and protect those who are most vulnerable to serious consequences of COVID-19. The population coverage required to achieve herd immunity through vaccination varies across diseases and is dependent on the basic reproduction number (R 0). 1 Modelling estimates R 0 to be around 2·5 for severe acute respiratory syndrome coronavirus 2 when no restrictions or physical distancing measures are in place, 2 and R 0 reached almost 4·0 in Wuhan in early-mid January, 2020. 3 Vaccination uptake for herd immunity would need to be at least 67% with an R 0 of 3·0. 1 In their Comment, the COCONEL Group reported that 26% of French adults would not accept a COVID-19 vaccine. 4 We similarly explored this question among a diverse sample of Australian adults. We conducted an online survey of 4362 Australians aged 18 years and older during April 17–21, approximately 4 weeks after lockdown measures had been activated in Australia and at a time when potential deaths and health system capacity were still of great concern. We asked participants about actions or intentions toward the flu vaccine (“I have or I will get the flu vaccine this year”) and a potential COVID-19 vaccine (“If a COVID-19 vaccine becomes available, I will get it”). In this sample, 630 (14·4%) participants said they would not get the flu vaccine this year, 394 (9·0%) were indifferent, and 3338 (76·5%) said they have or will get the flu vaccine this year. For a COVID-19 vaccine, 213 (4·9%) said they would not get the vaccine, 408 (9·4%) were indifferent, and 3741 (85·8%) said they would get the vaccine if it became available. Individuals who said they would not get a COVID-19 vaccine were more likely to believe the threat of COVID-19 has been exaggerated (43·7% [93/213]) than those who said they would get the vaccine if it became available (11·5% [429/3741]) and those who were indifferent (19·9% [81/408]). Inadequate health literacy and lower education level were significantly associated with a reluctance to be vaccinated against both influenza and COVID-19 (p<0·001; appendix). Notably, a high proportion overall were confident in the state (75·4% [3288/4362]) and federal (65·2% [2845/4362]) government's response. In Australia, attitudes towards a COVID-19 vaccine appear to be more positive than reported in France in late March, 4 which might in part reflect greater confidence in the government. However, our data show efforts are needed to target vaccine education to those with lower education and health literacy. 5 It remains to be seen whether Australia's high intentions towards vaccine uptake will remain when restrictions are relaxed and the immediate perceived threat diminishes.
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              Author and article information

              Journal
              Lancet Infect Dis
              Lancet Infect Dis
              The Lancet. Infectious Diseases
              Elsevier Ltd.
              1473-3099
              1474-4457
              14 September 2020
              14 September 2020
              Affiliations
              [a ]Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia
              [b ]Murdoch Children's Research Institute, Melbourne, VIC, Australia
              [c ]Department General Medicine, The Royal Children's Hospital Melbourne, Melbourne, VIC 3052, Australia
              [d ]Health Services Research Unit, The Royal Children's Hospital Melbourne, Melbourne, VIC 3052, Australia
              Article
              S1473-3099(20)30724-6
              10.1016/S1473-3099(20)30724-6
              7489926
              32941786
              debdf73d-fe29-4ced-b719-21e073897db0
              © 2020 Elsevier Ltd. All rights reserved.

              Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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              Infectious disease & Microbiology
              Infectious disease & Microbiology

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