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      Epidemiology and Clinical Presentation of COVID-19 in Older Adults

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          Synopsis

          SARS-CoV-2 infection remains asymptomatic in 33 to 90% of older adults depending on their immune status from prior infection, vaccination and circulating strain. Older adults symptomatic with SARS-CoV-2 often both present atypically, such as with a blunted fever response, and develop more severe disease. Early and late reports showed that older adults have increased severity of COVID-19 with higher case fatality rates and higher intensive care needs compared to younger adults. Infection and vaccine-induced antibody response and long-term effects of COVID-19 also differ in older adults.

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          Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

          Dawei Wang, Bo Hu, Fangfang Zhu … (2020)
          In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.
          Article 0 comments Cited 10841 times – based on 0 reviews     Review now
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            Is Open Access

            A pneumonia outbreak associated with a new coronavirus of probable bat origin

            Peng Zhou, Xing-Lou Yang, Xian-Guang Wang … (2020)
            Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats 1–4 . Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans 5–7 . Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.
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              Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

              Zunyou Wu, Jennifer M. McGoogan (2020)
              Article 0 comments Cited 8398 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Infect Dis Clin North Am
                Journal ID (iso-abbrev): Infect Dis Clin North Am
                Title: Infectious Disease Clinics of North America
                Publisher: Elsevier Health Sciences Division
                ISSN (Print): 0891-5520
                ISSN (Electronic): 1557-9824
                Publication date PMC-release: 4 November 2022
                Publication date (Electronic): 4 November 2022
                Affiliations
                [1 ]Center of Innovation in Long Term Services and Supports, Providence VA Medical Center, Providence, RI
                [2 ]Division of Geriatric and Palliative Medicine, Warren Alpert Medical School of Brown University, Providence, RI
                [3 ]Brown University School of Public Health Center for Gerontology and Healthcare Research
                Article
                Publisher Item ID: S0891-5520(22)00093-9
                DOI: 10.1016/j.idc.2022.11.001
                PMC ID: 9633621
                PubMed ID: 36805007
                SO-VID: de1ca30f-3d73-4333-838a-b2ba164e1e8f
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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                Subject: Article

                Keywords: covid-19,older adults,epidemiology,clinical presentation
                Data availability:
                Keywords: covid-19, older adults, epidemiology, clinical presentation

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