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Selection of Controls in Case-Control Studies: III. Design Options
May 01 1992
May 01 1992
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Abstract
Several design options available in the planning stage of case-control studies are
examined. Topics covered include matching, control/case ratio, choice of nested case-control
or case-cohort design, two-stage sampling, and other methods that can be used for
control selection. The effect of potential problems in obtaining comparable accuracy
of exposure is also examined. A discussion of the difficulty in meeting the principles
of study base, deconfounding, and comparable accuracy (S. Wacholder et al. Am J Epidemiol
1992;135:1019-28) in a single study completes this series of papers.