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      Research Progress of Artificial Intelligence Image Analysis in Systemic Disease-Related Ophthalmopathy

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          Abstract

          The eye is one of the most important organs of the human body. Eye diseases are closely related to other systemic diseases, both of which influence each other. Numerous systemic diseases lead to special clinical manifestations and complications in the eyes. Typical diseases include diabetic retinopathy, hypertensive retinopathy, thyroid associated ophthalmopathy, optic neuromyelitis, and Behcet's disease. Systemic disease-related ophthalmopathy is usually a chronic disease, and the analysis of imaging markers is helpful for a comprehensive diagnosis of these diseases. Recently, artificial intelligence (AI) technology based on deep learning has rapidly developed, leading to numerous achievements and arousing widespread concern. Presently, AI technology has made significant progress in research on imaging markers of systemic disease-related ophthalmopathy; however, there are also many limitations and challenges. This article reviews the research achievements, limitations, and future prospects of AI image analysis technology in systemic disease-related ophthalmopathy.

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          Most cited references52

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          Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs.

          Deep learning is a family of computational methods that allow an algorithm to program itself by learning from a large set of examples that demonstrate the desired behavior, removing the need to specify rules explicitly. Application of these methods to medical imaging requires further assessment and validation.
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            High-performance medicine: the convergence of human and artificial intelligence

            Eric Topol (2019)
            The use of artificial intelligence, and the deep-learning subtype in particular, has been enabled by the use of labeled big data, along with markedly enhanced computing power and cloud storage, across all sectors. In medicine, this is beginning to have an impact at three levels: for clinicians, predominantly via rapid, accurate image interpretation; for health systems, by improving workflow and the potential for reducing medical errors; and for patients, by enabling them to process their own data to promote health. The current limitations, including bias, privacy and security, and lack of transparency, along with the future directions of these applications will be discussed in this article. Over time, marked improvements in accuracy, productivity, and workflow will likely be actualized, but whether that will be used to improve the patient-doctor relationship or facilitate its erosion remains to be seen.
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              2020 International Society of Hypertension Global Hypertension Practice Guidelines

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                Author and article information

                Contributors
                Journal
                Dis Markers
                Dis Markers
                DM
                Disease Markers
                Hindawi
                0278-0240
                1875-8630
                2022
                24 June 2022
                : 2022
                : 3406890
                Affiliations
                1The Laboratory of Artificial Intelligence and Bigdata in Ophthalmology, Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China
                2School of Information Engineering, Huzhou University, Huzhou, China
                3Advanced Ophthalmology Laboratory (AOL), Robotrak Technologies, Nanjing, China
                4First Affiliated Hospital of Huzhou University, Huzhou, China
                Author notes

                Academic Editor: Yi Shao

                Author information
                https://orcid.org/0000-0002-0763-7990
                https://orcid.org/0000-0001-8049-1118
                https://orcid.org/0000-0001-7812-8555
                https://orcid.org/0000-0002-1064-1851
                https://orcid.org/0000-0001-7724-807X
                https://orcid.org/0000-0002-6531-0451
                https://orcid.org/0000-0002-1919-7953
                https://orcid.org/0000-0003-0541-4635
                https://orcid.org/0000-0002-7629-0193
                Article
                10.1155/2022/3406890
                9249504
                35783011
                dc2a57fd-dcf9-4b4c-bf07-45e9943fbd6b
                Copyright © 2022 Yuke Ji et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 20 April 2022
                : 9 June 2022
                Funding
                Funded by: National Computer Basic Education Research Association
                Award ID: 2021-AFCEC-566
                Funded by: Medical Science and Technology Development Project Fund of Nanjing
                Award ID: YKK21262
                Categories
                Review Article

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