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Fractional anisotropy of water diffusion in cerebral white matter across the lifespan
Author(s):
P. Kochunov
,
D.E. Williamson
,
J. Lancaster
,
P. Fox
,
J. Cornell
,
J. Blangero
,
D.C. Glahn
Publication date
Created:
January 2012
Publication date
(Print):
January 2012
Journal:
Neurobiology of Aging
Publisher:
Elsevier BV
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PMC
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Abstract
Determining the time of peak of cerebral maturation is vital for our understanding of when cerebral maturation ceases and the cerebral degeneration in healthy aging begins. We carefully mapped changes in fractional anisotropy (FA) of water diffusion for eleven major cerebral white matter tracts in a large group (831) of healthy human subjects aged 11-90. FA is a neuroimaging index of micro-structural white matter integrity, sensitive to age-related changes in cerebral myelin levels, measured using diffusion tensor imaging. The average FA values of cerebral white matter (WM) reached peak at the age 32 ± 6 years. FA measurements for all but one major cortical white matter tract (cortico-spinal) reached peaks between 23 and 39 years of age. The maturation rates, prior to age-of-peak were significantly correlated (r=0.74; p=0.01) with the rates of decline, past age-of-peak. Regional analysis of corpus callosum (CC) showed that thinly-myelinated, densely packed fibers in the genu, that connect pre-frontal areas, maturated later and showed higher decline in aging than the more thickly myelinated motor and sensory areas in the body and splenium of CC. Our findings can be summarized as: associative, cerebral WM tracts that reach their peak FA values later in life also show progressively higher age-related decline than earlier maturing motor and sensory tracts. These findings carry multiple and diverse implications for both theoretical studies of the neurobiology of maturation and aging and for the clinical studies of neuropsychiatric disorders. Copyright © 2010 Elsevier Inc. All rights reserved.
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Probing cerebral hemodynamics with BOLD fMRI
Author and article information
Journal
Title:
Neurobiology of Aging
Abbreviated Title:
Neurobiology of Aging
Publisher:
Elsevier BV
ISSN (Print):
01974580
Publication date Created:
January 2012
Publication date (Print):
January 2012
Volume
: 33
Issue
: 1
Pages
: 9-20
Article
DOI:
10.1016/j.neurobiolaging.2010.01.014
PMC ID:
2906767
PubMed ID:
20122755
SO-VID:
d7620ba5-5c63-4dfb-b43c-34f3a41d28b0
Copyright ©
© 2012
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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