We investigated laypersons’ agreement with technical claims about the spread of the Sars-CoV-2 virus and with claims about the risk from COVID-19 in the general public in Germany (N = 1,575) and compared these with the evaluations of scientific experts (N = 128). Using Latent Class Analysis, we distinguished four segments in the general public. Two groups (mainstream and cautious, 73%) are generally consistent with scientific experts in their evaluations. Two groups (doubters and deniers, 27%) differ distinctively from expert evaluations and tend to believe in conspiracies about COVID-19. Deniers (8%) are characterized by low risk assessments, anti-elitist sentiments and low compliance with containment measures. Doubters (19%) are characterized by general uncertainty in the distinction between true and false claims and by low scientific literacy in terms of cognitive ability and style. Our research indicates that conspiracy beliefs about COVID-19 cannot be linked to a single and distinct motivational structure.