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      Research Domain Criteria: toward future psychiatric nosologies Translated title: Criterios del ámbito de la investigación: hacia futuras nosologías psiquiátricas Translated title: Critères de domaines de recherche: vers une future nosologie psychiatrique

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          Abstract

          The Research Domain Criteria (RDoC) project was initiated by the National Institute of Mental Health (NIMH) in early 2009 as the implementation of Goal 1.4 of its just-issued strategic plan. In keeping with the NIMH mission, to “transform the understanding and treatment of mental illnesses through basic and clinical research,” RDoC was explicitly conceived as a research-related initiative. The statement of the relevant goal in the strategic plan reads: “Develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures.” Due to the novel approach that RDoC takes to conceptualizing and studying mental disorders, it has received widespread attention, well beyond the borders of the immediate research community. This review discusses the rationale for the experimental framework that RDoC has adopted, and its implications for the nosology of mental disorders in the future.

          Translated abstract

          A comienzos de 2009 el Instituto Nacional de Salud Mental (NIMH) lanzó el proyecto Criterios del Ámbito de la Investigación (RDoC) como parte de la implementación del Objetivo 1.4 de su recién publicado plan estratégico. En conformidad con la misión del NIMH, para “transformar la comprensión y el tratamiento de las en-fermedades mentales a través de la investigación básica y clínica” el RDoC fue concebido explícitamente como una iniciativa relacionada con la investigación. La declaración del objetivo pertinente en el plan estratégico señala: “Desarrollar, para propósitos de investigación nuevas vías de clasificación de los trastornos mentales en base a dimensiones observables de la conducta y mediciones neurobiológicas”. Debido al novedoso enfoque que tiene el RDoC para conceptualizar y estudiar los trastornos mentales, ha recibido gran atención, mucho más allá de las fronteras de la comunidad de investigación inmediata. Esta revisión discute los fundamentos del marco experimental que ha adoptado el RDoC y sus repercusiones futuras para la nosología de los trastor-nos mentales.

          Translated abstract

          Le NIMH (National Institute of Mental Health) a lancé le projet de « Critères de domaines de recherche » (CDoR) début 2009, en tant qu'application de l'objectif 1.4 de son plan stratégique venant d'être publié. Les CDoR ont été conçus explicitement comme une initiative liée à la recherche, en phase avec la mission du NIMH pour « transformer la compréhension et le traitement des maladies mentales par la recherche fondamentale et clinique ». L'objectif exposé dans le plan stratégique est le suivant: « Développer, aux fins de recherche, de nouvelles façons de classifier des troubles mentaux selon des critères de comportements observables et des mesures neurobiologiques ». Cette nouvelle approche des CDoR pour concevoir et étudier les troubles mentaux a reçu une grande attention, bien au-delà des frontières des communautés de chercheurs. Cet article analyse le fondement du cadre expérimental adopté par les CDoR et ses implications dans l'avenir pour la nosologie des troubles mentaux.

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          Most cited references47

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          Diagnostic and Statistical Manual of Mental Disorders

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            The WU-Minn Human Connectome Project: an overview.

            The Human Connectome Project consortium led by Washington University, University of Minnesota, and Oxford University is undertaking a systematic effort to map macroscopic human brain circuits and their relationship to behavior in a large population of healthy adults. This overview article focuses on progress made during the first half of the 5-year project in refining the methods for data acquisition and analysis. Preliminary analyses based on a finalized set of acquisition and preprocessing protocols demonstrate the exceptionally high quality of the data from each modality. The first quarterly release of imaging and behavioral data via the ConnectomeDB database demonstrates the commitment to making HCP datasets freely accessible. Altogether, the progress to date provides grounds for optimism that the HCP datasets and associated methods and software will become increasingly valuable resources for characterizing human brain connectivity and function, their relationship to behavior, and their heritability and genetic underpinnings. Copyright © 2013 Elsevier Inc. All rights reserved.
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              Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin.

              Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies. Copyright © 2014 Elsevier Inc. All rights reserved.
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                Author and article information

                Contributors
                Journal
                Dialogues Clin Neurosci
                Dialogues Clin Neurosci
                Dialogues Clin Neurosci
                Dialogues in Clinical Neuroscience
                Les Laboratoires Servier (France )
                1294-8322
                1958-5969
                March 2015
                March 2015
                : 17
                : 1
                : 89-97
                Affiliations
                National Institute of Mental Health, Bethesda, Maryland, USA
                Author notes
                Article
                10.31887/DCNS.2015.17.1/bcuthbert
                4421905
                25987867
                d53f96c5-76d2-4da4-8338-9fa0ca2eca93
                Copyright: © 2015 Institut la Conférence Hippocrate - Servier Research Group

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Categories
                Clinical Research

                Neurosciences
                psychiatric diagnosis,psychiatric nosology,rdoc,research domain criteria
                Neurosciences
                psychiatric diagnosis, psychiatric nosology, rdoc, research domain criteria

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